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- W2339263207 abstract "Synthetic vaccines offer one method to avoid the drawbacks associated with vaccines derived from whole organisms. This Perspective highlights the improvements and significant recent progress that has been achieved in developing well-defined synthetic vaccines using a variety of molecular antigens. Vaccines have typically been prepared using whole organisms. These are normally either attenuated bacteria or viruses that are live but have been altered to reduce their virulence, or pathogens that have been inactivated and effectively killed through exposure to heat or formaldehyde. However, using whole organisms to elicit an immune response introduces the potential for infections arising from a reversion to a virulent form in live pathogens, unproductive reactions to vaccine components or batch-to-batch variability. Synthetic vaccines, in which a molecular antigen is conjugated to a carrier protein, offer the opportunity to circumvent these problems. This Perspective will highlight the progress that has been achieved in developing synthetic vaccines using a variety of molecular antigens. In particular, the different approaches used to develop conjugate vaccines using peptide/proteins, carbohydrates and other small molecule haptens as antigens are compared." @default.
- W2339263207 created "2016-06-24" @default.
- W2339263207 creator A5000265622 @default.
- W2339263207 date "2015-11-20" @default.
- W2339263207 modified "2023-10-16" @default.
- W2339263207 title "Recent advances in the molecular design of synthetic vaccines" @default.
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- W2339263207 doi "https://doi.org/10.1038/nchem.2396" @default.
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