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• W2339265764 abstract "As microRNAs silence translation, rapid reversal of this process has emerged as an attractive mechanism for driving de novo protein synthesis mediating neuronal plasticity. Herein, we summarize recent studies identifying neuronal stimuli that trigger rapid decreases in microRNA levels and reverse translational silencing of plasticity transcripts. Although these findings indicate that neuronal stimulation elicits rapid degradation of selected microRNAs, we are only beginning to decipher the molecular pathways involved. Accordingly, we present an overview of several molecular pathways implicated in mediating microRNA degradation: Lin-28, translin/trax, and MCPIP1. As these degradation pathways target distinct subsets of microRNAs, they enable neurons to reverse silencing rapidly, yet selectively." @default.
• W2339265764 created "2016-06-24" @default.
• W2339265764 creator A5046684497 @default.
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• W2339265764 date "2016-09-01" @default.
• W2339265764 modified "2023-10-18" @default.
• W2339265764 title "Rapid reversal of translational silencing: Emerging role of microRNA degradation pathways in neuronal plasticity" @default.
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• W2339265764 doi "https://doi.org/10.1016/j.nlm.2016.04.006" @default.
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