FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2339283977> ?p ?o ?g. }

• W2339283977 endingPage "526" @default.
• W2339283977 startingPage "521" @default.
• W2339283977 abstract "Background Renal dysfunction (RD) is associated with reduced survival in HF; however, not all RD is mechanistically or prognostically equivalent. Notably, RD associated with “pre-renal” physiology, as identified by an elevated blood urea nitrogen to creatinine ratio (BUN/Cr), identifies a particularly high risk RD phenotype. Proteinuria, another domain of renal dysfunction, has also been associated with adverse events. Given that several different mechanisms can cause proteinuria, we sought to investigate whether the mechanism underlying proteinuria also affects survival in HF. Methods and Results Subjects in the Studies of Left Ventricular Dysfunction (SOLVD) trial with proteinuria assessed at baseline were studied (n = 6439). All survival models were adjusted for baseline characteristics and estimated glomerular filtration rate (eGFR). Proteinuria (trace or 1+) was present in 26% and associated with increased mortality (HR = 1.2; 95% CI, 1.1–1.3, p = 0.006). Proteinuria >1+ was less common (2.5%) but demonstrated a stronger relationship with mortality (HR = 1.9; 95% CI, 1.5–2.5, p < 0.001). In patients with BUN/Cr in the top tertile (≥17.3), any proteinuria (HR = 1.3; 95% CI, 1.1–1.5, p = 0.008) and >1+ proteinuria (HR = 2.3; 95% CI, 1.7–3.3, p < 0.001) both remained associated with mortality. However, in patients with BUN/Cr in the bottom tertile (≤13.3), any proteinuria (HR = 0.95; 95% CI, 0.77–1.2, p = 0.63, p interaction = 0.015) and >1+ proteinuria (HR = 1.3; 95% CI, 0.79–2.2, p = 0.29, p interaction = 0.036) were not associated with worsened survival. Conclusion Analogous to a reduced eGFR, the mechanism underlying proteinuria in HF may be important in determining the associated survival disadvantage." @default.
• W2339283977 created "2016-06-24" @default.
• W2339283977 creator A5000519502 @default.
• W2339283977 creator A5023587190 @default.
• W2339283977 creator A5040529362 @default.
• W2339283977 creator A5047653649 @default.
• W2339283977 creator A5047833899 @default.
• W2339283977 creator A5070205374 @default.
• W2339283977 creator A5088059687 @default.
• W2339283977 date "2016-07-01" @default.
• W2339283977 modified "2023-10-16" @default.
• W2339283977 title "The risk of death associated with proteinuria in heart failure is restricted to patients with an elevated blood urea nitrogen to creatinine ratio" @default.
• W2339283977 cites W1926244529 @default.
• W2339283977 cites W1970448985 @default.
• W2339283977 cites W1988685239 @default.
• W2339283977 cites W2015876671 @default.
• W2339283977 cites W2016186784 @default.
• W2339283977 cites W2021831645 @default.
• W2339283977 cites W2037181502 @default.
• W2339283977 cites W2038636008 @default.
• W2339283977 cites W2050005443 @default.
• W2339283977 cites W2055663701 @default.
• W2339283977 cites W2063007022 @default.
• W2339283977 cites W206576902 @default.
• W2339283977 cites W2069049295 @default.
• W2339283977 cites W2073742622 @default.
• W2339283977 cites W2074266942 @default.
• W2339283977 cites W2083932060 @default.
• W2339283977 cites W2101337080 @default.
• W2339283977 cites W2101636040 @default.
• W2339283977 cites W2104402487 @default.
• W2339283977 cites W2109864382 @default.
• W2339283977 cites W2123831918 @default.
• W2339283977 cites W2137092665 @default.
• W2339283977 cites W2145668639 @default.
• W2339283977 cites W2153028995 @default.
• W2339283977 cites W2153526796 @default.
• W2339283977 cites W2154128257 @default.
• W2339283977 cites W2154422770 @default.
• W2339283977 cites W2154768306 @default.
• W2339283977 cites W2169268865 @default.
• W2339283977 cites W2171320821 @default.
• W2339283977 cites W2224608232 @default.
• W2339283977 cites W2324579467 @default.
• W2339283977 cites W2469805673 @default.
• W2339283977 cites W2475261460 @default.
• W2339283977 cites W2585382523 @default.
• W2339283977 cites W4292543873 @default.
• W2339283977 doi "https://doi.org/10.1016/j.ijcard.2016.04.100" @default.
• W2339283977 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4986924" @default.
• W2339283977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27153048" @default.
• W2339283977 hasPublicationYear "2016" @default.
• W2339283977 type Work @default.
• W2339283977 sameAs 2339283977 @default.
• W2339283977 citedByCount "15" @default.
• W2339283977 countsByYear W23392839772016 @default.
• W2339283977 countsByYear W23392839772017 @default.
• W2339283977 countsByYear W23392839772019 @default.
• W2339283977 countsByYear W23392839772020 @default.
• W2339283977 countsByYear W23392839772021 @default.
• W2339283977 countsByYear W23392839772022 @default.
• W2339283977 crossrefType "journal-article" @default.
• W2339283977 hasAuthorship W2339283977A5000519502 @default.
• W2339283977 hasAuthorship W2339283977A5023587190 @default.
• W2339283977 hasAuthorship W2339283977A5040529362 @default.
• W2339283977 hasAuthorship W2339283977A5047653649 @default.
• W2339283977 hasAuthorship W2339283977A5047833899 @default.
• W2339283977 hasAuthorship W2339283977A5070205374 @default.
• W2339283977 hasAuthorship W2339283977A5088059687 @default.
• W2339283977 hasBestOaLocation W23392839772 @default.
• W2339283977 hasConcept C126322002 @default.
• W2339283977 hasConcept C126894567 @default.
• W2339283977 hasConcept C134018914 @default.
• W2339283977 hasConcept C159641895 @default.
• W2339283977 hasConcept C164705383 @default.
• W2339283977 hasConcept C2778176769 @default.
• W2339283977 hasConcept C2778198053 @default.
• W2339283977 hasConcept C2779561371 @default.
• W2339283977 hasConcept C2780091579 @default.
• W2339283977 hasConcept C2780306776 @default.
• W2339283977 hasConcept C71924100 @default.
• W2339283977 hasConcept C90924648 @default.
• W2339283977 hasConceptScore W2339283977C126322002 @default.
• W2339283977 hasConceptScore W2339283977C126894567 @default.
• W2339283977 hasConceptScore W2339283977C134018914 @default.
• W2339283977 hasConceptScore W2339283977C159641895 @default.
• W2339283977 hasConceptScore W2339283977C164705383 @default.
• W2339283977 hasConceptScore W2339283977C2778176769 @default.
• W2339283977 hasConceptScore W2339283977C2778198053 @default.
• W2339283977 hasConceptScore W2339283977C2779561371 @default.
• W2339283977 hasConceptScore W2339283977C2780091579 @default.
• W2339283977 hasConceptScore W2339283977C2780306776 @default.
• W2339283977 hasConceptScore W2339283977C71924100 @default.
• W2339283977 hasConceptScore W2339283977C90924648 @default.
• W2339283977 hasLocation W23392839771 @default.
• W2339283977 hasLocation W23392839772 @default.
• W2339283977 hasLocation W23392839773 @default.
• W2339283977 hasLocation W23392839774 @default.

• next