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• W2339338995 abstract "Targeted malaria control interventions are expected to be cost-effective. Clinical, parasitological and serological markers of malaria transmission have been used to detect malaria transmission hotspots, but few studies have examined the relationship between the different potential markers in low transmission areas. The present study reports on the relationships between clinical, parasitological, serological and entomological markers of malaria transmission in an area of low transmission intensity in Coastal Kenya.Longitudinal data collected from 831 children aged 5-17 months, cross-sectional survey data from 800 older children and adults, and entomological survey data collected in Ganze on the Kenyan Coast were used in the present study. The spatial scan statistic test used to detect malaria transmission hotspots was based on incidence of clinical malaria episodes, prevalence of asymptomatic asexual parasites carriage detected by microscopy and polymerase chain reaction (PCR), seroprevalence of antibodies to two Plasmodium falciparum merozoite antigens (AMA1 and MSP1-19) and densities of Anopheles mosquitoes in CDC light-trap catches.There was considerable overlapping of hotspots by these different markers, but only weak to moderate correlation between parasitological and serological markers. PCR prevalence and seroprevalence of antibodies to AMA1 or MSP1-19 appeared to be more sensitive markers of hotspots at very low transmission intensity.These findings may support the choice of either serology or PCR as markers in the detection of malaria transmission hotspots for targeted interventions." @default.
• W2339338995 created "2016-06-24" @default.
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• W2339338995 date "2016-04-14" @default.
• W2339338995 modified "2023-10-11" @default.
• W2339338995 title "Malaria hotspots defined by clinical malaria, asymptomatic carriage, PCR and vector numbers in a low transmission area on the Kenyan Coast" @default.
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• W2339338995 doi "https://doi.org/10.1186/s12936-016-1260-3" @default.
• W2339338995 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4831169" @default.
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