Matches in SemOpenAlex for { <https://semopenalex.org/work/W2339356498> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2339356498 endingPage "2546" @default.
- W2339356498 startingPage "2536" @default.
- W2339356498 abstract "1. The olfactory bulb contains high concentrations of zinc and copper. Whole cell recording techniques were used to examine the modulatory actions of zinc and copper on N-methyl-D-aspartate (NMDA), gamma-aminobutyric acid (GABA), and glycine receptors on rat olfactory bulb neurons in culture and acutely isolated from adult animals. 2. Zinc and copper were effective antagonists of both NMDA-and GABA-mediated currents. The median inhibiting concentrations (IC50s) for zinc were 19 microM for NMDA receptors and 17 microM for GABA receptors. The IC50s for copper were 22 microM for NMDA receptors and 18 microM for GABA receptors. 3. Zinc and copper (100 microM) had no effect on the steady-state, desensitized component of currents evoked by high concentrations of glycine (300 microM). In contrast, when low, nondesensitizing concentrations of glycine (30 microM) were used, 100 microM zinc dramatically potentiated the current and 100 microM copper blocked the current. 4. The effects of zinc and copper on NMDA-, GABA-, or glycine-mediated currents were not voltage dependent, irrespective of whether the effect was potentiation or inhibition. 5. These results provide the first evidence for an inhibitory effect of copper on NMDA receptors, and the first evidence that the effects of zinc and copper on glycine receptors are dependent on the state of the receptor. These results suggest that endogenous zinc and copper may act as allosteric neuromodulators of amino acid receptors on olfactory bulb neurons. Furthermore, zinc and copper may provide a mechanism for differential modulation of inhibitory transmission because of their distinct effects on glycine versus GABA receptors." @default.
- W2339356498 created "2016-06-24" @default.
- W2339356498 creator A5045524621 @default.
- W2339356498 creator A5065469901 @default.
- W2339356498 date "1996-10-01" @default.
- W2339356498 modified "2023-10-16" @default.
- W2339356498 title "Differential modulation by zinc and copper of amino acid receptors from rat olfactory bulb neurons" @default.
- W2339356498 doi "https://doi.org/10.1152/jn.1996.76.4.2536" @default.
- W2339356498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8899625" @default.
- W2339356498 hasPublicationYear "1996" @default.
- W2339356498 type Work @default.
- W2339356498 sameAs 2339356498 @default.
- W2339356498 citedByCount "117" @default.
- W2339356498 countsByYear W23393564982012 @default.
- W2339356498 countsByYear W23393564982013 @default.
- W2339356498 countsByYear W23393564982014 @default.
- W2339356498 countsByYear W23393564982015 @default.
- W2339356498 countsByYear W23393564982016 @default.
- W2339356498 countsByYear W23393564982017 @default.
- W2339356498 countsByYear W23393564982018 @default.
- W2339356498 countsByYear W23393564982019 @default.
- W2339356498 countsByYear W23393564982020 @default.
- W2339356498 countsByYear W23393564982021 @default.
- W2339356498 countsByYear W23393564982023 @default.
- W2339356498 crossrefType "journal-article" @default.
- W2339356498 hasAuthorship W2339356498A5045524621 @default.
- W2339356498 hasAuthorship W2339356498A5065469901 @default.
- W2339356498 hasConcept C12554922 @default.
- W2339356498 hasConcept C134018914 @default.
- W2339356498 hasConcept C170493617 @default.
- W2339356498 hasConcept C17077164 @default.
- W2339356498 hasConcept C178790620 @default.
- W2339356498 hasConcept C185592680 @default.
- W2339356498 hasConcept C2777756961 @default.
- W2339356498 hasConcept C2778938600 @default.
- W2339356498 hasConcept C2780496858 @default.
- W2339356498 hasConcept C35599011 @default.
- W2339356498 hasConcept C515207424 @default.
- W2339356498 hasConcept C529278444 @default.
- W2339356498 hasConcept C535196362 @default.
- W2339356498 hasConcept C55493867 @default.
- W2339356498 hasConcept C61174792 @default.
- W2339356498 hasConcept C67018056 @default.
- W2339356498 hasConcept C86803240 @default.
- W2339356498 hasConceptScore W2339356498C12554922 @default.
- W2339356498 hasConceptScore W2339356498C134018914 @default.
- W2339356498 hasConceptScore W2339356498C170493617 @default.
- W2339356498 hasConceptScore W2339356498C17077164 @default.
- W2339356498 hasConceptScore W2339356498C178790620 @default.
- W2339356498 hasConceptScore W2339356498C185592680 @default.
- W2339356498 hasConceptScore W2339356498C2777756961 @default.
- W2339356498 hasConceptScore W2339356498C2778938600 @default.
- W2339356498 hasConceptScore W2339356498C2780496858 @default.
- W2339356498 hasConceptScore W2339356498C35599011 @default.
- W2339356498 hasConceptScore W2339356498C515207424 @default.
- W2339356498 hasConceptScore W2339356498C529278444 @default.
- W2339356498 hasConceptScore W2339356498C535196362 @default.
- W2339356498 hasConceptScore W2339356498C55493867 @default.
- W2339356498 hasConceptScore W2339356498C61174792 @default.
- W2339356498 hasConceptScore W2339356498C67018056 @default.
- W2339356498 hasConceptScore W2339356498C86803240 @default.
- W2339356498 hasIssue "4" @default.
- W2339356498 hasLocation W23393564981 @default.
- W2339356498 hasLocation W23393564982 @default.
- W2339356498 hasOpenAccess W2339356498 @default.
- W2339356498 hasPrimaryLocation W23393564981 @default.
- W2339356498 hasRelatedWork W1510518012 @default.
- W2339356498 hasRelatedWork W1976772152 @default.
- W2339356498 hasRelatedWork W2044903229 @default.
- W2339356498 hasRelatedWork W2081678712 @default.
- W2339356498 hasRelatedWork W2118048149 @default.
- W2339356498 hasRelatedWork W2126808280 @default.
- W2339356498 hasRelatedWork W2198504477 @default.
- W2339356498 hasRelatedWork W2411662560 @default.
- W2339356498 hasRelatedWork W2417621838 @default.
- W2339356498 hasRelatedWork W4292210015 @default.
- W2339356498 hasVolume "76" @default.
- W2339356498 isParatext "false" @default.
- W2339356498 isRetracted "false" @default.
- W2339356498 magId "2339356498" @default.
- W2339356498 workType "article" @default.