Matches in SemOpenAlex for { <https://semopenalex.org/work/W2339366819> ?p ?o ?g. }
- W2339366819 abstract "Hemogen (Hemgn) is reported as a tissue specific transcriptional regulator in testis as well as hematopoietic tissues. It is known that Hemgn positively regulates erythroid differentiation; however, the underlying molecular mechanism is not well understood. In the current study, using proteomic approach in combination with other molecular biology tools, we have attempted to decipher the role of Hemgn in differentiating Murine erythroblast leukemia (MEL) cells as a model system. Our study reveals that Hemgn predominantly interacts with transcriptional regulators, chromatin modifiers and histones. Furthermore, using Chromatin Immunoprecipitation and knockdown approach, we have demonstrated that Hemgn is recruited to the -globin locus, which is known to be activated during erythroid differentiation. Based on the results, we speculate that Hemgn acts as a tissue specific histone chaperone that regulates transcription during erythroid" @default.
- W2339366819 created "2016-06-24" @default.
- W2339366819 creator A5090863446 @default.
- W2339366819 date "2012-01-01" @default.
- W2339366819 modified "2023-09-24" @default.
- W2339366819 title "Proteomic Characterization of Hemogen in Erythropoiesis" @default.
- W2339366819 cites W1508593718 @default.
- W2339366819 cites W1526134400 @default.
- W2339366819 cites W1547637047 @default.
- W2339366819 cites W1641120577 @default.
- W2339366819 cites W178179190 @default.
- W2339366819 cites W1839183617 @default.
- W2339366819 cites W1922163249 @default.
- W2339366819 cites W1937332911 @default.
- W2339366819 cites W1965081118 @default.
- W2339366819 cites W1968092959 @default.
- W2339366819 cites W1968628080 @default.
- W2339366819 cites W1973595140 @default.
- W2339366819 cites W1977843033 @default.
- W2339366819 cites W1982367790 @default.
- W2339366819 cites W1983985678 @default.
- W2339366819 cites W1987587793 @default.
- W2339366819 cites W1989736694 @default.
- W2339366819 cites W1991366673 @default.
- W2339366819 cites W1997031088 @default.
- W2339366819 cites W1999011979 @default.
- W2339366819 cites W2000686249 @default.
- W2339366819 cites W2011928168 @default.
- W2339366819 cites W2012610754 @default.
- W2339366819 cites W2015742390 @default.
- W2339366819 cites W2019289959 @default.
- W2339366819 cites W2021968590 @default.
- W2339366819 cites W2025847301 @default.
- W2339366819 cites W2026465178 @default.
- W2339366819 cites W2027900150 @default.
- W2339366819 cites W2028553942 @default.
- W2339366819 cites W2028764523 @default.
- W2339366819 cites W2029377035 @default.
- W2339366819 cites W2031864653 @default.
- W2339366819 cites W2035659472 @default.
- W2339366819 cites W2036795046 @default.
- W2339366819 cites W2037220886 @default.
- W2339366819 cites W2039748263 @default.
- W2339366819 cites W2046121370 @default.
- W2339366819 cites W2047285050 @default.
- W2339366819 cites W2048249977 @default.
- W2339366819 cites W2052436973 @default.
- W2339366819 cites W2053203603 @default.
- W2339366819 cites W2055310816 @default.
- W2339366819 cites W2056264836 @default.
- W2339366819 cites W2061776631 @default.
- W2339366819 cites W2070921472 @default.
- W2339366819 cites W2071238021 @default.
- W2339366819 cites W2079300137 @default.
- W2339366819 cites W2086243699 @default.
- W2339366819 cites W2089492568 @default.
- W2339366819 cites W2089894746 @default.
- W2339366819 cites W2093818708 @default.
- W2339366819 cites W2094431012 @default.
- W2339366819 cites W2095297122 @default.
- W2339366819 cites W2096083625 @default.
- W2339366819 cites W2101722176 @default.
- W2339366819 cites W2102433101 @default.
- W2339366819 cites W2103054294 @default.
- W2339366819 cites W2110816267 @default.
- W2339366819 cites W2112703508 @default.
- W2339366819 cites W2112985008 @default.
- W2339366819 cites W2113995752 @default.
- W2339366819 cites W2123347941 @default.
- W2339366819 cites W2127866040 @default.
- W2339366819 cites W2130350241 @default.
- W2339366819 cites W2137001129 @default.
- W2339366819 cites W2137043026 @default.
- W2339366819 cites W2138991271 @default.
- W2339366819 cites W2141991853 @default.
- W2339366819 cites W2143593035 @default.
- W2339366819 cites W2144085242 @default.
- W2339366819 cites W2144792857 @default.
- W2339366819 cites W2146256998 @default.
- W2339366819 cites W2146460428 @default.
- W2339366819 cites W2149290739 @default.
- W2339366819 cites W2149993601 @default.
- W2339366819 cites W2151396228 @default.
- W2339366819 cites W2156080468 @default.
- W2339366819 cites W2157658519 @default.
- W2339366819 cites W2158217645 @default.
- W2339366819 cites W2163771097 @default.
- W2339366819 cites W2169816095 @default.
- W2339366819 cites W2175853567 @default.
- W2339366819 cites W2338520289 @default.
- W2339366819 cites W2410485968 @default.
- W2339366819 cites W2417118679 @default.
- W2339366819 cites W2464298398 @default.
- W2339366819 cites W2004499293 @default.
- W2339366819 cites W2602662806 @default.
- W2339366819 cites W2755095224 @default.
- W2339366819 doi "https://doi.org/10.20381/ruor-3353" @default.
- W2339366819 hasPublicationYear "2012" @default.
- W2339366819 type Work @default.
- W2339366819 sameAs 2339366819 @default.