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- W2339377356 abstract "Objective:To observe the primary effect of therapy using a combination of insulin glargine(IG) and insulin aspart(IA) in children with type 1 diabetes. Methods:12 patients with type 1 diabetes were treated with IG and IA after using traditional treatment(Novolin 30R was used to subcutaneous inject,two-thirds of the amount half of an hour before breakfast,one-third of the amount half of an hour before dinner) . During the insulin analogues therapy,thrice-daily IA was used zero to fifteen minutes before meals plus once-daily IG before sleep. The numbers of nonsevere and severe hypoglycemic events,hemoglobin A1c values and daily insulin dose were recorded at each clinic visit. The clinical materials and the results of follow-up for 12 months were analyzed retrospectively in all patients. Results:All patients completed the study. The mean hemoglobin A1c levels were 9.51±0.71 %(baseline) ,9.12±0.82 % at 3 months(P0.05) ,8.61±0.87 % at 6 months(P0.05) ,8.71±0.68 % at 9 months(P0.05) ,8.65±0.79 % at 12 months(P0.05) . There was an insigni?cant decrease in daily insulin requirement in patients from 1.1±0.8 U/kg to 1.0±0.5 U/kg. The mean frequency of nonsevere hypoglycemic events per week decreased from 2.2±0.1 to 1.3±0.1. There was no severe hypoglycemic happened. Conclusion:The combined therapy of insulin glargine;insulin aspart is an effective treatment for children with type 1 diabetes mellitus than the traditional treatment. Without increasing the daily dose of insulin,the blood glucose was better controlled,the incidence of hypoglycemia was reduced in 3+1 treatment than in traditional treatment." @default.
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- W2339377356 date "2010-01-01" @default.
- W2339377356 modified "2023-09-27" @default.
- W2339377356 title "Combined therapy of insulin glargine (IG) and insulin aspart (IA) in children with type 1 diabetes mellitus: a primary observation." @default.
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