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- W2339384607 abstract "Morphological, immunophenotypic, and genetic analyses werecarriedouton peripheral blood,bone marrow,and pharyngealbiopsymaterialfrom a patientwithchronicmyelomonocytic leukaemia(CMML). Morphological analysis ofbonemarrowwasdiagnostic ofCMML; immunophenotypic analysis ofperipheral bloodandbonemarrow werenegative forB andT cellantigens, and immunochemistry performedon thepharyngeal extramedullary infiltrate showedthepresence oflargemonocytoid cellswhich stainedpositively for muramidase. Genotypic analysis, however, showedclonal rearrangement oftheT cell receptor (TCR)achaingene, amarkerofT cellor,lesscommonly,B celllymphoidneoplasms. OtherTCR genes,p and y,weregermlineinall tissues examined. TCR6isrearranged in precursor B cellandmostT lymphoid neoplasms. A smallproportion ofcases (10%)of acutemyeloidleukaemia (AML)alsoshowrearrangement ofthe TCRb gene.To dateTCR6 rearrangementhasnotbeendescribed inCMML. The aberrantTCRE5rearrangement shown in thispatientwith CMML provides further evidence oftheclonal natureofthis disorder. Analysis ofimmunoglobulin andT cell receptorgenerearrangements hasbeenshowntobe ofvalue inthedetermination ofclonality and, incertain circumstances, lineage ofavariety" @default.
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- W2339384607 date "1991-01-01" @default.
- W2339384607 modified "2023-09-26" @default.
- W2339384607 title "withT cell receptor 6 generearrangement" @default.
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