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- W2339409674 abstract "Microsomal prostaglandin E synthase-1 (mPGES-1) is the terminal enzyme for the synthesis of prostaglandin E 2 (PGE 2 ), a proproliferative and antiapoptotic lipid molecule important for tissue regeneration and injury repair. In this study, we developed transgenic (Tg) mice with targeted expression of mPGES-1 in the liver to assess Fas-induced hepatocyte apoptosis and acute liver injury. Compared with wild-type (WT) mice, the mPGES-1 Tg mice showed less liver hemorrhage, lower serum alanine transaminase (ALT) and aspartate transaminase (AST) levels, less hepatic necrosis/apoptosis, and lower level of caspase cascade activation after intraperitoneal injection of the anti-Fas antibody Jo2. Western blotting analysis revealed increased expression and activation of the serine/threonine kinase Akt and associated antiapoptotic molecules in the liver tissues of Jo2-treated mPGES-1 Tg mice. Pretreatment with the mPGES-1 inhibitor (MF63) or the Akt inhibitor (Akt inhibitor V) restored the susceptibility of the mPGES-1 Tg mice to Fas-induced liver injury. Our findings provide novel evidence that mPGES-1 prevents Fas-induced liver injury through activation of Akt and related signaling and suggest that induction of mPGES-1 or treatment with PGE 2 may represent important therapeutic strategy for the prevention and treatment of Fas-associated liver injuries." @default.
- W2339409674 created "2016-06-24" @default.
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- W2339409674 date "2016-06-01" @default.
- W2339409674 modified "2023-10-17" @default.
- W2339409674 title "Microsomal prostaglandin E synthase-1 protects against Fas-induced liver injury" @default.
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- W2339409674 doi "https://doi.org/10.1152/ajpgi.00327.2015" @default.
- W2339409674 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4935489" @default.
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