Matches in SemOpenAlex for { <https://semopenalex.org/work/W2339458284> ?p ?o ?g. }
Showing items 1 to 37 of
37
with 100 items per page.
- W2339458284 endingPage "112" @default.
- W2339458284 startingPage "107" @default.
- W2339458284 abstract "神经免疫在帕金森病（PD）的致病机理中发挥重要的作用,PD患者的外周血淋巴细胞的数量发生了变化,提示外周免疫系统在PD的发生发展中发挥一定的作用。但是外周单核细胞（PBMC）在其中发挥的具体作用尚不清楚。外源性神经毒素（MPTP）类似物,内源性神经毒素（NMSal）可能是导致PD发生的一种因素。研究采用NMSal损伤的SH-SY5Y与U87细胞共培养的条件性培养基培养外周单核细胞THP-1,探讨NMSal损伤的多巴胺能神经元细胞对外周单核细胞的影响。结果表明,该条件性培养基可以降低NMSal毒性诱导的THP-1细胞的凋亡、氧化应激水平（MDA和H2O2）、线粒体的损伤和凋亡相关蛋白FADD、Bax和caspase3的表达和活化水平。PD病人中损伤的多巴胺能神经元与星形胶质细胞的相互作用可能会影响PBMC,进而影响PD病情的进展。" @default.
- W2339458284 created "2016-06-24" @default.
- W2339458284 creator A5031288832 @default.
- W2339458284 creator A5068651501 @default.
- W2339458284 date "2015-01-01" @default.
- W2339458284 modified "2023-09-24" @default.
- W2339458284 title "SH-SYSH-SY5Y与UU87细胞共培养条件性培养基可降低N-甲基-salsolinol介导THP-THP-1细胞的凋亡" @default.
- W2339458284 hasPublicationYear "2015" @default.
- W2339458284 type Work @default.
- W2339458284 sameAs 2339458284 @default.
- W2339458284 citedByCount "0" @default.
- W2339458284 crossrefType "journal-article" @default.
- W2339458284 hasAuthorship W2339458284A5031288832 @default.
- W2339458284 hasAuthorship W2339458284A5068651501 @default.
- W2339458284 hasConcept C204258353 @default.
- W2339458284 hasConcept C2776715637 @default.
- W2339458284 hasConcept C2779083432 @default.
- W2339458284 hasConcept C54355233 @default.
- W2339458284 hasConcept C81885089 @default.
- W2339458284 hasConcept C86803240 @default.
- W2339458284 hasConceptScore W2339458284C204258353 @default.
- W2339458284 hasConceptScore W2339458284C2776715637 @default.
- W2339458284 hasConceptScore W2339458284C2779083432 @default.
- W2339458284 hasConceptScore W2339458284C54355233 @default.
- W2339458284 hasConceptScore W2339458284C81885089 @default.
- W2339458284 hasConceptScore W2339458284C86803240 @default.
- W2339458284 hasIssue "10" @default.
- W2339458284 hasLocation W23394582841 @default.
- W2339458284 hasOpenAccess W2339458284 @default.
- W2339458284 hasPrimaryLocation W23394582841 @default.
- W2339458284 hasVolume "33" @default.
- W2339458284 isParatext "false" @default.
- W2339458284 isRetracted "false" @default.
- W2339458284 magId "2339458284" @default.
- W2339458284 workType "article" @default.