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- W2339458811 abstract "Four new pregnanes, 3β,4β-dihydroxy-17-methyl-17α-pregna-5,13-diene-10,2-carbolactone (1), 6β-chloro-3β-hydroxy-17-methyl-17α-pregna-4,13-diene-10,2-carbolactone (2), 3β-hydroxy-6β-methoxy-17-methyl-17α-pregna-4,13-diene-10,2-carbolactone (3), and 3β,6β-dihydroxy-17-methyl-17α-pregna-4,13-diene-10,2-carbolactone (4), were isolated from an undescribed species of Myrmekioderma Ehlers along with the known pregnane carbolactone (5). The structures of the new compounds were determined by spectroscopic methods and comparison with previously described compounds. Compound 5 showed almost 4-fold activation of pregnane X receptor, while 2 inhibited BACE1 with an IC50 value of 82 μM." @default.
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- W2339458811 date "2016-04-22" @default.
- W2339458811 modified "2023-09-30" @default.
- W2339458811 title "Pregnane-10,2-carbolactones from a Hawaiian Marine Sponge in the Genus <i>Myrmekioderma</i>" @default.
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- W2339458811 doi "https://doi.org/10.1021/acs.jnatprod.6b00042" @default.
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