FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2339468052> ?p ?o ?g. }

• W2339468052 endingPage "C1803" @default.
• W2339468052 startingPage "C1797" @default.
• W2339468052 abstract "Insulin stimulates K(+) uptake and Na(+) efflux via the Na(+)-K(+) pump in kidney, skeletal muscle, and brain. The mechanism of insulin action in these tissues differs, in part, because of differences in the isoform complement of the catalytic alpha-subunit of the Na(+)-K(+) pump. To analyze specifically the effect of insulin on the alpha(1)-isoform of the pump, we have studied human embryonic kidney (HEK)-293 cells stably transfected with the rat Na(+)-K(+) pump alpha(1)-isoform tagged on its first exofacial loop with a hemagglutinin (HA) epitope. The plasma membrane content of alpha(1)-subunits was quantitated by binding a specific HA antibody to intact cells. Insulin rapidly increased the number of alpha(1)-subunits at the cell surface. This gain was sensitive to the phosphatidylinositol (PI) 3-kinase inhibitor wortmannin and to the protein kinase C (PKC) inhibitor bisindolylmaleimide. Furthermore, the insulin-stimulated gain in surface alpha-subunits correlated with an increase in the binding of an antibody that recognizes only the nonphosphorylated form of alpha(1) (at serine-18). These results suggest that insulin regulates the Na(+)-K(+) pump in HEK-293 cells, at least in part, by decreasing serine phosphorylation and increasing plasma membrane content of alpha(1)-subunits via a signaling pathway involving PI 3-kinase and PKC." @default.
• W2339468052 created "2016-06-24" @default.
• W2339468052 creator A5001315042 @default.
• W2339468052 creator A5012313326 @default.
• W2339468052 creator A5055522505 @default.
• W2339468052 creator A5064467789 @default.
• W2339468052 creator A5070111620 @default.
• W2339468052 date "2001-12-01" @default.
• W2339468052 modified "2023-09-29" @default.
• W2339468052 title "Insulin increases plasma membrane content and reduces phosphorylation of Na⁺-K⁺pump α₁-subunit in HEK-293 cells" @default.
• W2339468052 cites W1481860092 @default.
• W2339468052 cites W1514745038 @default.
• W2339468052 cites W1541553752 @default.
• W2339468052 cites W1548022389 @default.
• W2339468052 cites W1551967741 @default.
• W2339468052 cites W1562290896 @default.
• W2339468052 cites W1591165395 @default.
• W2339468052 cites W1643628872 @default.
• W2339468052 cites W1966012343 @default.
• W2339468052 cites W1969563969 @default.
• W2339468052 cites W1970705861 @default.
• W2339468052 cites W1971040655 @default.
• W2339468052 cites W1989822987 @default.
• W2339468052 cites W1996983786 @default.
• W2339468052 cites W2020662324 @default.
• W2339468052 cites W2025998518 @default.
• W2339468052 cites W2026979523 @default.
• W2339468052 cites W2039400789 @default.
• W2339468052 cites W2045984022 @default.
• W2339468052 cites W2046762902 @default.
• W2339468052 cites W2051119776 @default.
• W2339468052 cites W2062346517 @default.
• W2339468052 cites W2067817632 @default.
• W2339468052 cites W2068959694 @default.
• W2339468052 cites W2069229224 @default.
• W2339468052 cites W2081562689 @default.
• W2339468052 cites W2111678246 @default.
• W2339468052 cites W2141940718 @default.
• W2339468052 cites W2142567521 @default.
• W2339468052 cites W2152899125 @default.
• W2339468052 cites W2154238429 @default.
• W2339468052 cites W2154916238 @default.
• W2339468052 cites W2160370971 @default.
• W2339468052 cites W2175631194 @default.
• W2339468052 cites W2185757795 @default.
• W2339468052 cites W2187659172 @default.
• W2339468052 cites W2225263353 @default.
• W2339468052 cites W2339282460 @default.
• W2339468052 cites W2341150623 @default.
• W2339468052 cites W2415416371 @default.
• W2339468052 cites W2422733973 @default.
• W2339468052 doi "https://doi.org/10.1152/ajpcell.2001.281.6.c1797" @default.
• W2339468052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11698237" @default.
• W2339468052 hasPublicationYear "2001" @default.
• W2339468052 type Work @default.
• W2339468052 sameAs 2339468052 @default.
• W2339468052 citedByCount "32" @default.
• W2339468052 countsByYear W23394680522012 @default.
• W2339468052 countsByYear W23394680522013 @default.
• W2339468052 countsByYear W23394680522014 @default.
• W2339468052 countsByYear W23394680522015 @default.
• W2339468052 countsByYear W23394680522016 @default.
• W2339468052 countsByYear W23394680522020 @default.
• W2339468052 countsByYear W23394680522021 @default.
• W2339468052 countsByYear W23394680522023 @default.
• W2339468052 crossrefType "journal-article" @default.
• W2339468052 hasAuthorship W2339468052A5001315042 @default.
• W2339468052 hasAuthorship W2339468052A5012313326 @default.
• W2339468052 hasAuthorship W2339468052A5055522505 @default.
• W2339468052 hasAuthorship W2339468052A5064467789 @default.
• W2339468052 hasAuthorship W2339468052A5070111620 @default.
• W2339468052 hasConcept C104292427 @default.
• W2339468052 hasConcept C104317684 @default.
• W2339468052 hasConcept C11960822 @default.
• W2339468052 hasConcept C12554922 @default.
• W2339468052 hasConcept C153911025 @default.
• W2339468052 hasConcept C170493617 @default.
• W2339468052 hasConcept C174510640 @default.
• W2339468052 hasConcept C185592680 @default.
• W2339468052 hasConcept C195794163 @default.
• W2339468052 hasConcept C2778308172 @default.
• W2339468052 hasConcept C2780610907 @default.
• W2339468052 hasConcept C54009773 @default.
• W2339468052 hasConcept C55493867 @default.
• W2339468052 hasConcept C83730767 @default.
• W2339468052 hasConcept C86803240 @default.
• W2339468052 hasConcept C95444343 @default.
• W2339468052 hasConceptScore W2339468052C104292427 @default.
• W2339468052 hasConceptScore W2339468052C104317684 @default.
• W2339468052 hasConceptScore W2339468052C11960822 @default.
• W2339468052 hasConceptScore W2339468052C12554922 @default.
• W2339468052 hasConceptScore W2339468052C153911025 @default.
• W2339468052 hasConceptScore W2339468052C170493617 @default.
• W2339468052 hasConceptScore W2339468052C174510640 @default.
• W2339468052 hasConceptScore W2339468052C185592680 @default.
• W2339468052 hasConceptScore W2339468052C195794163 @default.
• W2339468052 hasConceptScore W2339468052C2778308172 @default.
• W2339468052 hasConceptScore W2339468052C2780610907 @default.

• next