FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2339623449> ?p ?o ?g. }

• W2339623449 endingPage "35445" @default.
• W2339623449 startingPage "35437" @default.
• W2339623449 abstract "// Guoxing Wan 1 , Xiongjie Yu 1 , Ping Chen 1 , Xianhe Wang 1 , Dongfeng Pan 1 , Xuanbin Wang 1 , Linjun Li 1 , Xiaojun Cai 1 and Fengjun Cao 1 1 Department of Oncology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, China Correspondence to: Fengjun Cao, email: // Xiaojun Cai, email: // Keywords : lung cancer, metformin, survival, diabetes, meta-analysis Received : October 29, 2015 Accepted : April 11, 2016 Published : April 20, 2016 Abstract The purpose of this study is to summarize the currently available evidence regarding the concerned issue by performing a comprehensive meta-analysis. Relevant publications reporting the association of metformin use with survival of lung cancer patients with diabetes were electronically searched to identify eligible studies. The meta-analysis was performed with hazard ratios (HRs) and 95% confidence intervals (95% CIs) as effect measures for disease-free survival(DFS) and overall survival(OS) estimates. A total of 17 individual studies from 10 publications were included in the meta-analysis. Overall, the results revealed a significant association of metformin use with a better survival of lung cancer patients with diabetes(for DFS: HR = 0.65, 95%CI = 0.52-0.83; for OS: HR = 0.78, 95%CI = 0.64-0.93). The subgroup analyses showed similar association in Asian region(for DFS:HR = 0.69, 95%CI = 0.59-0.80; for OS: HR = 0.55, 95%CI = 0.46-0.67) but not in Western region. Such association was also presented in small cell lung cancer (for DFS: HR = 0.54, 95%CI = 0.38-0.77; for OS: HR = 0.52, 95%CI = 0.39-0.69) and in non-small cell lung cancer(for DFS: HR = 0.70, 95%CI = 0.51-0.96; for OS: HR = 0.75, 95%CI = 0.58- 0.97). Analyses stratified by treatment strategy showed a reduction in the risk of cancer-related mortality in patients receiving chemotherapy(for DFS: HR = 0.71, 95%CI = 0.64-0.83; for OS: HR = 0.58, 95%CI = 0.47-0.71) but not in patients receiving chemoradiotherapy. The meta-analysis demonstrated that metformin use was significantly associated with a favorable survival outcome of lung cancer patients with diabetes." @default.
• W2339623449 created "2016-06-24" @default.
• W2339623449 creator A5005713522 @default.
• W2339623449 creator A5013705512 @default.
• W2339623449 creator A5016950354 @default.
• W2339623449 creator A5022317683 @default.
• W2339623449 creator A5035961866 @default.
• W2339623449 creator A5053948940 @default.
• W2339623449 creator A5060220713 @default.
• W2339623449 creator A5065848115 @default.
• W2339623449 creator A5089285560 @default.
• W2339623449 date "2016-04-20" @default.
• W2339623449 modified "2023-10-10" @default.
• W2339623449 title "Metformin therapy associated with survival benefit in lung cancer patients with diabetes" @default.
• W2339623449 cites W1496178984 @default.
• W2339623449 cites W1541546104 @default.
• W2339623449 cites W1698712530 @default.
• W2339623449 cites W1758894002 @default.
• W2339623449 cites W1881105800 @default.
• W2339623449 cites W1896068127 @default.
• W2339623449 cites W1932188075 @default.
• W2339623449 cites W1964435302 @default.
• W2339623449 cites W1965380846 @default.
• W2339623449 cites W1976655891 @default.
• W2339623449 cites W1978119991 @default.
• W2339623449 cites W1988782755 @default.
• W2339623449 cites W1993095144 @default.
• W2339623449 cites W2010450183 @default.
• W2339623449 cites W2013047715 @default.
• W2339623449 cites W2038991262 @default.
• W2339623449 cites W2039152216 @default.
• W2339623449 cites W2076582761 @default.
• W2339623449 cites W2076908467 @default.
• W2339623449 cites W2080501822 @default.
• W2339623449 cites W2084459692 @default.
• W2339623449 cites W2096315962 @default.
• W2339623449 cites W2098167876 @default.
• W2339623449 cites W2100349150 @default.
• W2339623449 cites W2105050951 @default.
• W2339623449 cites W2107328434 @default.
• W2339623449 cites W2116475791 @default.
• W2339623449 cites W2125435699 @default.
• W2339623449 cites W2126646540 @default.
• W2339623449 cites W2129620555 @default.
• W2339623449 cites W2134309588 @default.
• W2339623449 cites W2146511561 @default.
• W2339623449 cites W2148672071 @default.
• W2339623449 cites W2150000105 @default.
• W2339623449 cites W2151151767 @default.
• W2339623449 cites W2157823046 @default.
• W2339623449 cites W2188417988 @default.
• W2339623449 cites W2231596189 @default.
• W2339623449 cites W2233709418 @default.
• W2339623449 cites W2261720738 @default.
• W2339623449 cites W2273029502 @default.
• W2339623449 cites W2281067753 @default.
• W2339623449 cites W2345237583 @default.
• W2339623449 doi "https://doi.org/10.18632/oncotarget.8881" @default.
• W2339623449 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5085241" @default.
• W2339623449 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27105507" @default.
• W2339623449 hasPublicationYear "2016" @default.
• W2339623449 type Work @default.
• W2339623449 sameAs 2339623449 @default.
• W2339623449 citedByCount "50" @default.
• W2339623449 countsByYear W23396234492016 @default.
• W2339623449 countsByYear W23396234492017 @default.
• W2339623449 countsByYear W23396234492018 @default.
• W2339623449 countsByYear W23396234492019 @default.
• W2339623449 countsByYear W23396234492020 @default.
• W2339623449 countsByYear W23396234492021 @default.
• W2339623449 countsByYear W23396234492022 @default.
• W2339623449 countsByYear W23396234492023 @default.
• W2339623449 crossrefType "journal-article" @default.
• W2339623449 hasAuthorship W2339623449A5005713522 @default.
• W2339623449 hasAuthorship W2339623449A5013705512 @default.
• W2339623449 hasAuthorship W2339623449A5016950354 @default.
• W2339623449 hasAuthorship W2339623449A5022317683 @default.
• W2339623449 hasAuthorship W2339623449A5035961866 @default.
• W2339623449 hasAuthorship W2339623449A5053948940 @default.
• W2339623449 hasAuthorship W2339623449A5060220713 @default.
• W2339623449 hasAuthorship W2339623449A5065848115 @default.
• W2339623449 hasAuthorship W2339623449A5089285560 @default.
• W2339623449 hasBestOaLocation W23396234491 @default.
• W2339623449 hasConcept C121608353 @default.
• W2339623449 hasConcept C126322002 @default.
• W2339623449 hasConcept C134018914 @default.
• W2339623449 hasConcept C143998085 @default.
• W2339623449 hasConcept C187960798 @default.
• W2339623449 hasConcept C207103383 @default.
• W2339623449 hasConcept C2776256026 @default.
• W2339623449 hasConcept C2779306644 @default.
• W2339623449 hasConcept C2780323712 @default.
• W2339623449 hasConcept C44249647 @default.
• W2339623449 hasConcept C555293320 @default.
• W2339623449 hasConcept C71924100 @default.
• W2339623449 hasConcept C95190672 @default.
• W2339623449 hasConceptScore W2339623449C121608353 @default.
• W2339623449 hasConceptScore W2339623449C126322002 @default.

• next