FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2339635118> ?p ?o ?g. }

• W2339635118 endingPage "3387" @default.
• W2339635118 startingPage "3377" @default.
• W2339635118 abstract "Neonatal forelimb removal in rats results in the development of inappropriate hindlimb inputs in the forelimb-stump representation of primary somatosensory cortex (S-I) that are revealed when GABA(A) and GABA(B) receptor activity are blocked. Experiments carried out to date have not made clear what information is being suppressed at the level of individual neurons. In this study, three potential ways in which GABA-mediated inhibition could suppress hindlimb expression in the S-I stump representation were evaluated: silencing S-I neurons with dual stump and hindlimb receptive fields, silencing neurons with receptive fields restricted to the hindlimb alone, and/or selective silencing of hindlimb inputs to neurons that normally express a stump receptive field only. These possibilities were tested using single-unit recording techniques to evaluate the receptive fields of S-I forelimb-stump neurons before, during, and after blockade of GABA receptors with bicuculline methiodide (for GABA(A)) and saclofen (for GABA(B)). Recordings were also made from normal rats for comparison. Of 92 neurons recorded from the S-I stump representation of neonatally amputated rats, only 2.2% had receptive fields that included the hindlimb prior to GABA receptor blockade. During GABA receptor blockade, 54.3% of these cells became responsive to the hindlimb, and in all but two cases, these same neurons also expressed a stump receptive field. Most of these cells (82.0%) expressed only stump receptive fields prior to GABA receptor blockade. In 71 neurons recorded from normal rats, only 5 became responsive to the hindlimb during GABA receptor blockade. GABA receptor blockade of cortical neurons, in both normal and neonatally amputated rats, resulted in significant enlargements of receptive fields as well as the emergence of receptive fields for neurons that were normally unresponsive. GABA receptor blockade also resulted in increases in both the spontaneous activity and response magnitudes of these neurons. These data support the conclusion that GABA mechanisms generally act to specifically suppress hindlimb inputs to S-I forelimb-stump neurons that normally express a receptive field on the forelimb stump only." @default.
• W2339635118 created "2016-06-24" @default.
• W2339635118 creator A5000584616 @default.
• W2339635118 creator A5054903905 @default.
• W2339635118 creator A5058347768 @default.
• W2339635118 creator A5073973332 @default.
• W2339635118 date "2000-06-01" @default.
• W2339635118 modified "2023-09-23" @default.
• W2339635118 title "Suppression of Hindlimb Inputs to S-I Forelimb-Stump Representation of Rats With Neonatal Forelimb Removal: GABA Receptor Blockade and Single-Cell Responses" @default.
• W2339635118 cites W1770152808 @default.
• W2339635118 cites W1835874403 @default.
• W2339635118 cites W1840999135 @default.
• W2339635118 cites W1887392787 @default.
• W2339635118 cites W1964435647 @default.
• W2339635118 cites W1968131916 @default.
• W2339635118 cites W1968193584 @default.
• W2339635118 cites W1970075526 @default.
• W2339635118 cites W1972994374 @default.
• W2339635118 cites W1981136283 @default.
• W2339635118 cites W1982791959 @default.
• W2339635118 cites W1988923525 @default.
• W2339635118 cites W1994969025 @default.
• W2339635118 cites W2010572823 @default.
• W2339635118 cites W2011829737 @default.
• W2339635118 cites W2024121985 @default.
• W2339635118 cites W2025835100 @default.
• W2339635118 cites W2032431935 @default.
• W2339635118 cites W2036890922 @default.
• W2339635118 cites W2037651918 @default.
• W2339635118 cites W2039030743 @default.
• W2339635118 cites W2039980517 @default.
• W2339635118 cites W2040200937 @default.
• W2339635118 cites W2044464067 @default.
• W2339635118 cites W2047615424 @default.
• W2339635118 cites W2048683767 @default.
• W2339635118 cites W2050780736 @default.
• W2339635118 cites W2051600803 @default.
• W2339635118 cites W2061670620 @default.
• W2339635118 cites W2061982365 @default.
• W2339635118 cites W2079360703 @default.
• W2339635118 cites W2081291986 @default.
• W2339635118 cites W2084155385 @default.
• W2339635118 cites W2091587722 @default.
• W2339635118 cites W2094285918 @default.
• W2339635118 cites W2095168842 @default.
• W2339635118 cites W2097404399 @default.
• W2339635118 cites W2104640624 @default.
• W2339635118 cites W2107824553 @default.
• W2339635118 cites W2122755381 @default.
• W2339635118 cites W2140241125 @default.
• W2339635118 cites W2186169542 @default.
• W2339635118 cites W2238204934 @default.
• W2339635118 cites W2306563575 @default.
• W2339635118 cites W2312572943 @default.
• W2339635118 cites W2341272969 @default.
• W2339635118 cites W4235306208 @default.
• W2339635118 doi "https://doi.org/10.1152/jn.2000.83.6.3377" @default.
• W2339635118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10848556" @default.
• W2339635118 hasPublicationYear "2000" @default.
• W2339635118 type Work @default.
• W2339635118 sameAs 2339635118 @default.
• W2339635118 citedByCount "22" @default.
• W2339635118 countsByYear W23396351182013 @default.
• W2339635118 countsByYear W23396351182014 @default.
• W2339635118 countsByYear W23396351182015 @default.
• W2339635118 countsByYear W23396351182016 @default.
• W2339635118 countsByYear W23396351182020 @default.
• W2339635118 countsByYear W23396351182021 @default.
• W2339635118 crossrefType "journal-article" @default.
• W2339635118 hasAuthorship W2339635118A5000584616 @default.
• W2339635118 hasAuthorship W2339635118A5054903905 @default.
• W2339635118 hasAuthorship W2339635118A5058347768 @default.
• W2339635118 hasAuthorship W2339635118A5073973332 @default.
• W2339635118 hasConcept C105702510 @default.
• W2339635118 hasConcept C126322002 @default.
• W2339635118 hasConcept C168258287 @default.
• W2339635118 hasConcept C169760540 @default.
• W2339635118 hasConcept C170493617 @default.
• W2339635118 hasConcept C172497186 @default.
• W2339635118 hasConcept C19071747 @default.
• W2339635118 hasConcept C2778468042 @default.
• W2339635118 hasConcept C2778646069 @default.
• W2339635118 hasConcept C2780763569 @default.
• W2339635118 hasConcept C51738704 @default.
• W2339635118 hasConcept C71924100 @default.
• W2339635118 hasConcept C86803240 @default.
• W2339635118 hasConceptScore W2339635118C105702510 @default.
• W2339635118 hasConceptScore W2339635118C126322002 @default.
• W2339635118 hasConceptScore W2339635118C168258287 @default.
• W2339635118 hasConceptScore W2339635118C169760540 @default.
• W2339635118 hasConceptScore W2339635118C170493617 @default.
• W2339635118 hasConceptScore W2339635118C172497186 @default.
• W2339635118 hasConceptScore W2339635118C19071747 @default.
• W2339635118 hasConceptScore W2339635118C2778468042 @default.
• W2339635118 hasConceptScore W2339635118C2778646069 @default.
• W2339635118 hasConceptScore W2339635118C2780763569 @default.
• W2339635118 hasConceptScore W2339635118C51738704 @default.
• W2339635118 hasConceptScore W2339635118C71924100 @default.

• next