FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2339797972> ?p ?o ?g. }

• W2339797972 abstract "c-Myc has been proposed as a putative target gene of signal transducer and activator of transcription 5 (STAT5). No functional STAT5 binding site has been identified so far within the c-Myc gene locus, therefore a direct transcriptional regulation by STAT5 remains uncertain. c-Myc super-enhancer, located 1.7 Mb downstream of the c-Myc gene locus, was recently reported as essential for the regulation of c-Myc gene expression by hematopoietic transcription factors and bromodomain and extra-terminal (BET) proteins and for leukemia maintenance. c-Myc super-enhancer is composed of five regulatory regions (E1–E5) which recruit transcription and chromatin-associated factors, mediating chromatin looping and interaction with the c-Myc promoter. We now show that STAT5 strongly binds to c-Myc super-enhancer regions E3 and E4, both in normal and transformed Ba/F3 cells. We also found that the BET protein bromodomain-containing protein 2 (BRD2), a co-factor of STAT5, co-localizes with STAT5 at E3/E4 in Ba/F3 cells transformed by the constitutively active STAT5-1*6 mutant, but not in non-transformed Ba/F3 cells. BRD2 binding at E3/E4 coincides with c-Myc transcriptional activation and is lost upon treatment with deacetylase and BET inhibitors, both of which inhibit STAT5 transcriptional activity and c-Myc gene expression. Our data suggest that constitutive STAT5 binding to c-Myc super-enhancer might contribute to BRD2 maintenance and thus allow sustained expression of c-Myc in Ba/F3 cells transformed by STAT5-1*6." @default.
• W2339797972 created "2016-06-24" @default.
• W2339797972 creator A5019077858 @default.
• W2339797972 creator A5042641484 @default.
• W2339797972 creator A5081807669 @default.
• W2339797972 date "2016-04-14" @default.
• W2339797972 modified "2023-09-26" @default.
• W2339797972 title "Signal transducer and activator of transcription STAT5 is recruited to c-Myc super-enhancer" @default.
• W2339797972 cites W1526798002 @default.
• W2339797972 cites W1595597462 @default.
• W2339797972 cites W1917578864 @default.
• W2339797972 cites W1968109606 @default.
• W2339797972 cites W1968924661 @default.
• W2339797972 cites W1999367215 @default.
• W2339797972 cites W2004430410 @default.
• W2339797972 cites W2008409819 @default.
• W2339797972 cites W2009949436 @default.
• W2339797972 cites W2023278718 @default.
• W2339797972 cites W2024457272 @default.
• W2339797972 cites W2031570299 @default.
• W2339797972 cites W2033753214 @default.
• W2339797972 cites W2039975110 @default.
• W2339797972 cites W2041535798 @default.
• W2339797972 cites W2044780532 @default.
• W2339797972 cites W2045133943 @default.
• W2339797972 cites W2046085162 @default.
• W2339797972 cites W2046982014 @default.
• W2339797972 cites W2049548558 @default.
• W2339797972 cites W2066680949 @default.
• W2339797972 cites W2070597688 @default.
• W2339797972 cites W2075214128 @default.
• W2339797972 cites W2091417752 @default.
• W2339797972 cites W2104830066 @default.
• W2339797972 cites W2105550924 @default.
• W2339797972 cites W2107077050 @default.
• W2339797972 cites W2108455002 @default.
• W2339797972 cites W2110378711 @default.
• W2339797972 cites W2112953655 @default.
• W2339797972 cites W2113890278 @default.
• W2339797972 cites W2115186999 @default.
• W2339797972 cites W2118953824 @default.
• W2339797972 cites W2129024737 @default.
• W2339797972 cites W2130649080 @default.
• W2339797972 cites W2135177247 @default.
• W2339797972 cites W2148261329 @default.
• W2339797972 cites W2152981209 @default.
• W2339797972 cites W2153879016 @default.
• W2339797972 cites W2154279096 @default.
• W2339797972 cites W2160845426 @default.
• W2339797972 cites W2162384201 @default.
• W2339797972 cites W2162723598 @default.
• W2339797972 cites W2168964329 @default.
• W2339797972 cites W2169287961 @default.
• W2339797972 cites W2172042768 @default.
• W2339797972 cites W2224782492 @default.
• W2339797972 cites W2312984480 @default.
• W2339797972 cites W2539181834 @default.
• W2339797972 cites W4553897 @default.
• W2339797972 doi "https://doi.org/10.1186/s12867-016-0063-y" @default.
• W2339797972 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4831086" @default.
• W2339797972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27074708" @default.
• W2339797972 hasPublicationYear "2016" @default.
• W2339797972 type Work @default.
• W2339797972 sameAs 2339797972 @default.
• W2339797972 citedByCount "39" @default.
• W2339797972 countsByYear W23397979722016 @default.
• W2339797972 countsByYear W23397979722017 @default.
• W2339797972 countsByYear W23397979722018 @default.
• W2339797972 countsByYear W23397979722019 @default.
• W2339797972 countsByYear W23397979722020 @default.
• W2339797972 countsByYear W23397979722021 @default.
• W2339797972 countsByYear W23397979722022 @default.
• W2339797972 countsByYear W23397979722023 @default.
• W2339797972 crossrefType "journal-article" @default.
• W2339797972 hasAuthorship W2339797972A5019077858 @default.
• W2339797972 hasAuthorship W2339797972A5042641484 @default.
• W2339797972 hasAuthorship W2339797972A5081807669 @default.
• W2339797972 hasBestOaLocation W23397979721 @default.
• W2339797972 hasConcept C101762097 @default.
• W2339797972 hasConcept C104317684 @default.
• W2339797972 hasConcept C111936080 @default.
• W2339797972 hasConcept C119157956 @default.
• W2339797972 hasConcept C134320426 @default.
• W2339797972 hasConcept C150194340 @default.
• W2339797972 hasConcept C153911025 @default.
• W2339797972 hasConcept C171958077 @default.
• W2339797972 hasConcept C21784809 @default.
• W2339797972 hasConcept C2778923194 @default.
• W2339797972 hasConcept C2779391668 @default.
• W2339797972 hasConcept C54355233 @default.
• W2339797972 hasConcept C74401373 @default.
• W2339797972 hasConcept C83640560 @default.
• W2339797972 hasConcept C86339819 @default.
• W2339797972 hasConcept C86803240 @default.
• W2339797972 hasConcept C88045685 @default.
• W2339797972 hasConceptScore W2339797972C101762097 @default.
• W2339797972 hasConceptScore W2339797972C104317684 @default.
• W2339797972 hasConceptScore W2339797972C111936080 @default.
• W2339797972 hasConceptScore W2339797972C119157956 @default.
• W2339797972 hasConceptScore W2339797972C134320426 @default.

• next