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• W2339805656 abstract "Objective: Antibiotic resistance in Gram negative bacteria is an increasing problem worldwide and a challenging issue for the physicians in both nosocomial and community-acquired infections. Infections caused by metallo-beta-lactamase (MBL)-producing bacteria are particularly threatening as the resistance genes of these bacteria may render an entire antibiotic class ineffective. Moreover, the rates of multidrug-resistant strains are also higher among MBL-producing bacteria. Multidrug resistance has been gradually increasing among non-fermentative Gram-negative bacilli (NFGNB). The present study aimed to investigate resistance rates of carbapenem-resistant NFGNB isolated from patients’ specimens to other antibiotics and to evaluate MBL production by E-test method. Method: Carbapenem-resistant NFGNB, which were isolated from the inpatients’ specimens sent from January 2014 through March 2015 to Ankara Numune Training and Research Hospital Medical Microbiology Laboratory, were included. Imipenemand/or meropenem-resistant strains were considered as carbapenem-resistant. Meropenem/meropenem+EDTA E-test strips were used for phenotypic MBL detection. Results: The study included 110 carbapenemresistant NFGNB strains. Of these strains, 44.5% were Acinetobacter baumannii and 36.4% were Pseudomonas aeruginosa. The NFGNB strains were mostly isolated from tracheal aspirate (37.9%), followed by blood (22.3%), wound (17.5%), and urine (13.6%) specimens. When all carbapenem-resistant NFGNB strains were considered, the highest rate of resistance was ampicillin-sulbactam OZET Amac: Gram negatif bakterilerde gorulen antibiyotik direnci tum dunyada giderek artan bir sorundur ve hem hastane ici hem de toplum kokenli enfeksiyonlarda hekimleri zorlayan bir konudur. Metallo-beta-laktamaz (MBL) ureten bakteriler ile olusan enfeksiyonlar ozellikle endise vericidir; cunku bu bakterilerdeki direnc genleri bir sinif antibiyotigin tumunu etkisiz kilabilirler. Ayrica, MBL ureten bakteriler arasinda coklu ilac direncli suslarin orani da yuksek olmaktadir. Coklu ilac direnci non-fermenter Gram negatif basiller (NFGNB) arasinda giderek artis gostermektedir. Bu calismada, hasta orneklerinden izole edilen karbapenem direncli NFGNB (non-fermenter Gram negatif basiller)’de diger antibiyotiklere direnc oranlarinin ve E-test yontemi ile MBL uretiminin arastirilmasi amaclanmistir. Yontem: Ankara Numune Egitim ve Arastirma Hastanesi Tibbi Mikrobiyoloji Laboratuvarina Ocak 2014 ve Mart 2015 yillari arasinda gonderilen yatan hasta orneklerinden izole edilen karbapenem direncli NFGNB calismaya dahil edilmistir. Imipenem ve/veya meropenem direncli suslar karbapenem direncli olarak kabul edilmistir. Fenotipik olarak MBL tayini icin meropenem/ meropenem+EDTA E-test stripleri kullanilmistir. Bulgular: Calismaya 110 karbapenem direncli NFGNB sus dahil edilmistir. Bunlarin %44,5’i Acinetobacter baumannii, %36,4’u Pseudomonas aeruginosa’dir. NFGNB suslarinin en fazla izole edildigi ornek trakeal aspirat (%37,9) olup bunu %22,3 ile kan, %17,5 ile yara ve %13,6 ile idrar ornegi izlemistir. Karbapenem direncli tum NFGNB Makale Dili “Ingilizce”/Article Language “English”" @default.
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• W2339805656 date "2016-01-01" @default.
• W2339805656 modified "2023-10-12" @default.
• W2339805656 title "Antibiotic Resistance and Metallo-Beta-Lactamase Positivity in Carbapenem-Resistant Non-Fermentative Gram-Negative Bacilli" @default.
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• W2339805656 doi "https://doi.org/10.5505/turkhijyen.2016.55706" @default.
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