Matches in SemOpenAlex for { <https://semopenalex.org/work/W2339807029> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2339807029 endingPage "1045" @default.
- W2339807029 startingPage "1038" @default.
- W2339807029 abstract "BACKGROUND The objective was to estimate the incidence‐based costs of treating β‐thalassemia major (BTM) to the United Kingdom's National Health Service (NHS) over the first 50 years of a patient's life in terms of healthcare resource use and corresponding costs and the associated health outcomes. STUDY DESIGN AND METHODS This was a modeling study based on information obtained from a systematic review of published literature and clinicians involved in managing BTM in the United Kingdom. A state transition model was constructed depicting the management of BTM over a period of 50 years. The model was used to estimate the incidence‐based health economic impact that BTM imposes on the NHS and patients' health status in terms of the number of quality‐adjusted life‐years (QALYs) over 50 years. RESULTS The expected probability of survival at 50 years is 0.63. Of patients who survive, 33% are expected to be without any complication and the other 67% are expected to experience at least one complication. Patients' health status over this period was estimated to be a mean of 11.5 discounted QALYs per patient. Total healthcare expenditure attributable to managing BTM was estimated to be £483,454 ($720,201) at 2013/14 prices over 50 years. The cost of managing BTM could be potentially reduced by up to 37% if one in two patients had a bone marrow transplant, with an ensuing improvement in health‐related quality of life. CONCLUSION This analysis provides the best estimate available of NHS resource use and costs with which to inform policy and budgetary decisions pertaining to this rare disease." @default.
- W2339807029 created "2016-06-24" @default.
- W2339807029 creator A5003866278 @default.
- W2339807029 creator A5005130583 @default.
- W2339807029 creator A5017339649 @default.
- W2339807029 date "2016-04-04" @default.
- W2339807029 modified "2023-10-15" @default.
- W2339807029 title "Healthcare costs and outcomes of managing β-thalassemia major over 50 years in the United Kingdom" @default.
- W2339807029 cites W1565330151 @default.
- W2339807029 cites W1974602569 @default.
- W2339807029 cites W1986776379 @default.
- W2339807029 cites W2019157254 @default.
- W2339807029 cites W2019433045 @default.
- W2339807029 cites W2022281178 @default.
- W2339807029 cites W2030996596 @default.
- W2339807029 cites W2031245623 @default.
- W2339807029 cites W2034307554 @default.
- W2339807029 cites W2043084465 @default.
- W2339807029 cites W2069918539 @default.
- W2339807029 cites W2076748772 @default.
- W2339807029 cites W2077429231 @default.
- W2339807029 cites W2101516869 @default.
- W2339807029 cites W2106602960 @default.
- W2339807029 cites W2112154893 @default.
- W2339807029 cites W2117460722 @default.
- W2339807029 cites W2123974278 @default.
- W2339807029 cites W2128195071 @default.
- W2339807029 cites W2139685175 @default.
- W2339807029 cites W2152992933 @default.
- W2339807029 cites W2158222954 @default.
- W2339807029 cites W2159746403 @default.
- W2339807029 cites W2168793485 @default.
- W2339807029 doi "https://doi.org/10.1111/trf.13513" @default.
- W2339807029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27041389" @default.
- W2339807029 hasPublicationYear "2016" @default.
- W2339807029 type Work @default.
- W2339807029 sameAs 2339807029 @default.
- W2339807029 citedByCount "47" @default.
- W2339807029 countsByYear W23398070292017 @default.
- W2339807029 countsByYear W23398070292018 @default.
- W2339807029 countsByYear W23398070292019 @default.
- W2339807029 countsByYear W23398070292020 @default.
- W2339807029 countsByYear W23398070292021 @default.
- W2339807029 countsByYear W23398070292022 @default.
- W2339807029 countsByYear W23398070292023 @default.
- W2339807029 crossrefType "journal-article" @default.
- W2339807029 hasAuthorship W2339807029A5003866278 @default.
- W2339807029 hasAuthorship W2339807029A5005130583 @default.
- W2339807029 hasAuthorship W2339807029A5017339649 @default.
- W2339807029 hasConcept C112930515 @default.
- W2339807029 hasConcept C120665830 @default.
- W2339807029 hasConcept C121332964 @default.
- W2339807029 hasConcept C159110408 @default.
- W2339807029 hasConcept C160735492 @default.
- W2339807029 hasConcept C162324750 @default.
- W2339807029 hasConcept C187212893 @default.
- W2339807029 hasConcept C2779951463 @default.
- W2339807029 hasConcept C3019080777 @default.
- W2339807029 hasConcept C50522688 @default.
- W2339807029 hasConcept C61511704 @default.
- W2339807029 hasConcept C64332521 @default.
- W2339807029 hasConcept C71924100 @default.
- W2339807029 hasConcept C99454951 @default.
- W2339807029 hasConceptScore W2339807029C112930515 @default.
- W2339807029 hasConceptScore W2339807029C120665830 @default.
- W2339807029 hasConceptScore W2339807029C121332964 @default.
- W2339807029 hasConceptScore W2339807029C159110408 @default.
- W2339807029 hasConceptScore W2339807029C160735492 @default.
- W2339807029 hasConceptScore W2339807029C162324750 @default.
- W2339807029 hasConceptScore W2339807029C187212893 @default.
- W2339807029 hasConceptScore W2339807029C2779951463 @default.
- W2339807029 hasConceptScore W2339807029C3019080777 @default.
- W2339807029 hasConceptScore W2339807029C50522688 @default.
- W2339807029 hasConceptScore W2339807029C61511704 @default.
- W2339807029 hasConceptScore W2339807029C64332521 @default.
- W2339807029 hasConceptScore W2339807029C71924100 @default.
- W2339807029 hasConceptScore W2339807029C99454951 @default.
- W2339807029 hasIssue "5" @default.
- W2339807029 hasLocation W23398070291 @default.
- W2339807029 hasLocation W23398070292 @default.
- W2339807029 hasOpenAccess W2339807029 @default.
- W2339807029 hasPrimaryLocation W23398070291 @default.
- W2339807029 hasRelatedWork W1501205893 @default.
- W2339807029 hasRelatedWork W1998957566 @default.
- W2339807029 hasRelatedWork W2036989460 @default.
- W2339807029 hasRelatedWork W2057334354 @default.
- W2339807029 hasRelatedWork W2100632149 @default.
- W2339807029 hasRelatedWork W2160572201 @default.
- W2339807029 hasRelatedWork W2344334115 @default.
- W2339807029 hasRelatedWork W2363171232 @default.
- W2339807029 hasRelatedWork W2365507823 @default.
- W2339807029 hasRelatedWork W2977838860 @default.
- W2339807029 hasVolume "56" @default.
- W2339807029 isParatext "false" @default.
- W2339807029 isRetracted "false" @default.
- W2339807029 magId "2339807029" @default.
- W2339807029 workType "article" @default.