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- W2339853485 abstract "Vaccines are available against human papillomavirus (HPV), the causal agent of cervical and other cancers. Efficacy data from the HPV-16/18 AS04-adjuvanted vaccine clinical trial program were reviewed. Six randomized, controlled phase II/III trials evaluating cervical endpoints enrolled women from diverse populations and geographical locations. The program analyzed extensively the cohorts most relevant from a public health perspective: the total vaccinated cohort (TVC), approximating a general population including those with existing or previous HPV infection, and TVC-naïve, approximating a population of young women before sexual debut. Results show that the vaccine reduces HPV-16/18 infection and associated cervical endpoints in women regardless of age, location, or sexual experience. It provides cross-protection against some non-vaccine oncogenic HPV types and types causing genital warts, and may be effective against vulvar, oral, and anal HPV infection. Early epidemiology data following its introduction suggest a decline in the prevalence of vaccine and some non-vaccine HPV types." @default.
- W2339853485 created "2016-06-24" @default.
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- W2339853485 date "2016-02-22" @default.
- W2339853485 modified "2023-09-24" @default.
- W2339853485 title "Human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine for the prevention of cervical cancer and HPV-related diseases" @default.
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- W2339853485 doi "https://doi.org/10.1586/14760584.2016.1124763" @default.
- W2339853485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26902666" @default.
- W2339853485 hasPublicationYear "2016" @default.