FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2339893802> ?p ?o ?g. }

• W2339893802 endingPage "456" @default.
• W2339893802 startingPage "451" @default.
• W2339893802 abstract "Relaxin is a peptide hormone best known for its action during the latter half of pregnancy, in particular for its softening effect on pelvic ligaments that aids in preparation of the birth canal for the impending delivery of the fetus. The source of relaxin during early pregnancy varies across species, with the CL being the main source in a number of species. The main source of relaxin during late equine pregnancy is the placenta. In mares with impaired placental function, circulating relaxin levels decline before abortion. During early pregnancy, relaxin promotes endometrial angiogenesis through upregulating endometrial expression of vascular endothelial growth factor. The horse is unique in that the equine conceptus expresses relaxin messenger RNA as early as 8 days after ovulation, with levels increasing as conceptus development proceeds. Although secretion of functional relaxin has not been verified, it is likely, given that the embryo also expresses transcripts coding for enzymes processing the prohormone to yield the mature hormone. Furin, an enzyme which belongs to the subtilisin-like proprotein convertase family known to process preprorelaxin, appears to be the foremost convertase expressed by equine conceptuses. Conceptus-derived relaxin could drive endometrial angiogenesis and also act in an autocrine fashion to promote the embryo's own development. Relaxin is also expressed by ovarian structures during the nonpregnant estrous cycle. In the mare, follicular expression of relaxin is comparable among follicles of varying size and has been localized to granulosa and theca cells. In women and pigs, relaxin appears to promote follicular development. In the rat, multiple lines of evidence indicate that relaxin is involved in the ovulatory process. In the mare, relaxin might play a similar role in the ovulatory process, as in equine ovarian stromal cells relaxin promotes the secretion of gelatinases and tissue inhibitors of metalloproteinases; local proteolysis of the follicular wall is integral to the ovulatory process. However, functional studies addressing the role of relaxin in the ovulatory process are missing in the mare." @default.
• W2339893802 created "2016-06-24" @default.
• W2339893802 creator A5056118165 @default.
• W2339893802 date "2016-07-01" @default.
• W2339893802 modified "2023-09-23" @default.
• W2339893802 title "The role of relaxin in mare reproductive physiology: A comparative review with other species" @default.
• W2339893802 cites W1509556419 @default.
• W2339893802 cites W1538634378 @default.
• W2339893802 cites W1953950040 @default.
• W2339893802 cites W1969353470 @default.
• W2339893802 cites W1970468102 @default.
• W2339893802 cites W1976843216 @default.
• W2339893802 cites W1977707284 @default.
• W2339893802 cites W1978557182 @default.
• W2339893802 cites W1979206567 @default.
• W2339893802 cites W1982955008 @default.
• W2339893802 cites W1985127594 @default.
• W2339893802 cites W1996468270 @default.
• W2339893802 cites W2005499349 @default.
• W2339893802 cites W2005857816 @default.
• W2339893802 cites W2008668286 @default.
• W2339893802 cites W2011449661 @default.
• W2339893802 cites W2012020894 @default.
• W2339893802 cites W2014992854 @default.
• W2339893802 cites W2017247290 @default.
• W2339893802 cites W2017815826 @default.
• W2339893802 cites W2018082219 @default.
• W2339893802 cites W2027756690 @default.
• W2339893802 cites W2031341480 @default.
• W2339893802 cites W2033955551 @default.
• W2339893802 cites W2034629140 @default.
• W2339893802 cites W2044796109 @default.
• W2339893802 cites W2046312642 @default.
• W2339893802 cites W2046687927 @default.
• W2339893802 cites W2047459062 @default.
• W2339893802 cites W2053330417 @default.
• W2339893802 cites W2053852776 @default.
• W2339893802 cites W2057891123 @default.
• W2339893802 cites W2071979007 @default.
• W2339893802 cites W2075287278 @default.
• W2339893802 cites W2076125605 @default.
• W2339893802 cites W2077908533 @default.
• W2339893802 cites W2078488366 @default.
• W2339893802 cites W2081096440 @default.
• W2339893802 cites W2084696027 @default.
• W2339893802 cites W2085119552 @default.
• W2339893802 cites W2085522770 @default.
• W2339893802 cites W2090442412 @default.
• W2339893802 cites W2090675349 @default.
• W2339893802 cites W2099040307 @default.
• W2339893802 cites W2106709674 @default.
• W2339893802 cites W2111503111 @default.
• W2339893802 cites W2121722776 @default.
• W2339893802 cites W2122408361 @default.
• W2339893802 cites W2123167726 @default.
• W2339893802 cites W2128671083 @default.
• W2339893802 cites W2131288493 @default.
• W2339893802 cites W2131482417 @default.
• W2339893802 cites W2136428504 @default.
• W2339893802 cites W2145387518 @default.
• W2339893802 cites W2154120641 @default.
• W2339893802 cites W2154235686 @default.
• W2339893802 cites W2154313874 @default.
• W2339893802 cites W2155819536 @default.
• W2339893802 cites W2160462719 @default.
• W2339893802 cites W2160667315 @default.
• W2339893802 cites W2162725324 @default.
• W2339893802 cites W2163619065 @default.
• W2339893802 cites W2164132683 @default.
• W2339893802 cites W2165237422 @default.
• W2339893802 cites W2166087688 @default.
• W2339893802 cites W2168099466 @default.
• W2339893802 cites W2184457894 @default.
• W2339893802 cites W2246398117 @default.
• W2339893802 cites W2295915366 @default.
• W2339893802 cites W2316368673 @default.
• W2339893802 cites W2321048056 @default.
• W2339893802 cites W2418118744 @default.
• W2339893802 doi "https://doi.org/10.1016/j.theriogenology.2016.04.061" @default.
• W2339893802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27158127" @default.
• W2339893802 hasPublicationYear "2016" @default.
• W2339893802 type Work @default.
• W2339893802 sameAs 2339893802 @default.
• W2339893802 citedByCount "15" @default.
• W2339893802 countsByYear W23398938022017 @default.
• W2339893802 countsByYear W23398938022018 @default.
• W2339893802 countsByYear W23398938022019 @default.
• W2339893802 countsByYear W23398938022020 @default.
• W2339893802 countsByYear W23398938022021 @default.
• W2339893802 countsByYear W23398938022022 @default.
• W2339893802 countsByYear W23398938022023 @default.
• W2339893802 crossrefType "journal-article" @default.
• W2339893802 hasAuthorship W2339893802A5056118165 @default.
• W2339893802 hasConcept C126322002 @default.
• W2339893802 hasConcept C134018914 @default.
• W2339893802 hasConcept C172680121 @default.
• W2339893802 hasConcept C187785154 @default.
• W2339893802 hasConcept C2776608385 @default.

• next