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- W2339926377 abstract "Background: Alcohol dependence (AD) is a serious and common public health problem. A large number of association studies were conducted to identify susceptibility genes of AD, but efforts to generate an integrate view of accumulative genetic variants and pathways under alcohol drinking are lacking. Methods: We applied enrichment gene set analysis to existing genetic association results to identify pertinent pathways to alcohol dependence in this study. A total of 1438 SNPs (P < 1.0 × 10 −3 ) associated to alcohol drinking related-traits have been collected from 31 studies. Results: The calcium signaling pathway (hsa04020) showed the most significant enrichment of associations (21 genes) to alcohol consumption phenotypes (P = 5.4 × 10 −5 ), achieving bonferroni P value of 0.8 × 10 −3 and FDR value of 0.6 × 10 −2 , respectively. Interestingly, the calcium signaling pathway was previously found to be essential to regulate brain function. Genes in this pathway link to a depressive effect of alcohol consumption on the body. Conclusions: Our find- ings, together with previous biological evidence suggest the importance of gene polymorphisms of calcium signaling pathway to alcohol dependence susceptibility." @default.
- W2339926377 created "2016-06-24" @default.
- W2339926377 creator A5023696154 @default.
- W2339926377 date "2014-01-01" @default.
- W2339926377 modified "2023-09-26" @default.
- W2339926377 title "Pathway Analysis Suggest the Calcium Signaling Pathway Associated with Alcohol Dependence" @default.
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