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- W2339934195 abstract "From the Department of Medicine, Baylor College of Medicine, and the Infectious Disease Section, St. Luke's Episcopal Hospital, Houston, Texas. Requests for reprints should be addressed to Dr. Layne O. Gentry, Infectious Disease Section, St. Luke's Episcopal Hospital, 6720 Bertner, Box 233, Houston, Texas 77030. Monotherapy of osteomyelitis with the newer broad-spectrum betalactam antibiotics has become attractive because of the efficacy, safety, and cost of these antibiotics when compared with conventional combination therapy. Imipenem/cilastatin is a recent and promising addition to this antibiotic family. Experience with imipenem/cilastatin and that reported for cefotaxime, ceffazidime, and ceftizoxime in the treatment of biopsy-proved osteomyelitis was compared, using data from published reports from five centers. Two hundred forty-three patients were evaluable: 34 were treated with imipenem/cilastatin, 84 with cefotaxime, 122 with ceftazidime, and 33 with ceftizoxime. Staphylococcus aureus was isolated by 80 bone cultures and was the most common single species encountered. There were 75 isolates of Pseudomonas aeruginosa, 113 mixed Enterobacteriaceae species, 115 mixed gram-positive and -negative isolates of miscellaneous species, and 30 anerobic isolates. Polymicrobial infection was present in 101 cases (41.6 percent). Failure rates were similarly low in all groups (10 to 30 percent). However, resistance developed during therapy in all groups with P. aeruginosa. Side effects were predictably few, but reversible neutropenia, pseudomembranous colitis due to Clostridium difficile, and nausea required therapy to be discontinued in seven patients. Imipenem/cilastatin should prove to be a very effective and relatively safe single agent for treatment of osteomyelitis." @default.
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- W2339934195 date "1985-01-01" @default.
- W2339934195 modified "2023-09-23" @default.
- W2339934195 title "Role for Newer Beta-Lactam Antibiotics in TTTR" @default.
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