Matches in SemOpenAlex for { <https://semopenalex.org/work/W2339941932> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2339941932 abstract "Abstract Tumor vasculatures express high levels of α(V)β(3)/α(V)β(5) and α(5)β(1) integrins. Peptide containing the RGD (Arg-Gly-Asp) sequence, which is present in ligands of integrins, is effective in targeting therapeutic reagents to tumor vascular endothelium. In this study, we investigated whether the biological activity of endostatin 27 peptides can be enhanced by the addition of an integrin targeting sequence. RGDRGD and GGGRGD sequence were added to the carboxyl terminus of endostatin 27 and 25 peptides, respectively. Modification of endostatin 27 peptides with the RGD motif showed specific and increased binding to endothelial cells and the increased binding is consistent with improved antiangiogenic property. RGD-modified endostatin 27 peptides was more effective than human endostatin and endostatin 27 peptides in inhibiting liver cancer growth in athymic mice. These finding indicates that addition of a vascular targeting sequence can enhance the biological activity of an antiangiogenic peptides molecule." @default.
- W2339941932 created "2016-06-24" @default.
- W2339941932 creator A5032886328 @default.
- W2339941932 creator A5035697458 @default.
- W2339941932 creator A5040014899 @default.
- W2339941932 creator A5080259158 @default.
- W2339941932 creator A5083106935 @default.
- W2339941932 date "2011-06-15" @default.
- W2339941932 modified "2023-09-23" @default.
- W2339941932 title "An RGD-Modified Endostatin Peptide Expressed at E. coli Shows Anti-Tumor Activity In vivo." @default.
- W2339941932 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21675950" @default.
- W2339941932 hasPublicationYear "2011" @default.
- W2339941932 type Work @default.
- W2339941932 sameAs 2339941932 @default.
- W2339941932 citedByCount "1" @default.
- W2339941932 countsByYear W23399419322012 @default.
- W2339941932 crossrefType "journal-article" @default.
- W2339941932 hasAuthorship W2339941932A5032886328 @default.
- W2339941932 hasAuthorship W2339941932A5035697458 @default.
- W2339941932 hasAuthorship W2339941932A5040014899 @default.
- W2339941932 hasAuthorship W2339941932A5080259158 @default.
- W2339941932 hasAuthorship W2339941932A5083106935 @default.
- W2339941932 hasConcept C104317684 @default.
- W2339941932 hasConcept C116073593 @default.
- W2339941932 hasConcept C150903083 @default.
- W2339941932 hasConcept C153911025 @default.
- W2339941932 hasConcept C167625842 @default.
- W2339941932 hasConcept C170493617 @default.
- W2339941932 hasConcept C185592680 @default.
- W2339941932 hasConcept C195687474 @default.
- W2339941932 hasConcept C202751555 @default.
- W2339941932 hasConcept C207001950 @default.
- W2339941932 hasConcept C2779281246 @default.
- W2339941932 hasConcept C2779358239 @default.
- W2339941932 hasConcept C2780394083 @default.
- W2339941932 hasConcept C502942594 @default.
- W2339941932 hasConcept C55493867 @default.
- W2339941932 hasConcept C75920679 @default.
- W2339941932 hasConcept C86803240 @default.
- W2339941932 hasConceptScore W2339941932C104317684 @default.
- W2339941932 hasConceptScore W2339941932C116073593 @default.
- W2339941932 hasConceptScore W2339941932C150903083 @default.
- W2339941932 hasConceptScore W2339941932C153911025 @default.
- W2339941932 hasConceptScore W2339941932C167625842 @default.
- W2339941932 hasConceptScore W2339941932C170493617 @default.
- W2339941932 hasConceptScore W2339941932C185592680 @default.
- W2339941932 hasConceptScore W2339941932C195687474 @default.
- W2339941932 hasConceptScore W2339941932C202751555 @default.
- W2339941932 hasConceptScore W2339941932C207001950 @default.
- W2339941932 hasConceptScore W2339941932C2779281246 @default.
- W2339941932 hasConceptScore W2339941932C2779358239 @default.
- W2339941932 hasConceptScore W2339941932C2780394083 @default.
- W2339941932 hasConceptScore W2339941932C502942594 @default.
- W2339941932 hasConceptScore W2339941932C55493867 @default.
- W2339941932 hasConceptScore W2339941932C75920679 @default.
- W2339941932 hasConceptScore W2339941932C86803240 @default.
- W2339941932 hasLocation W23399419321 @default.
- W2339941932 hasLocation W23399419322 @default.
- W2339941932 hasOpenAccess W2339941932 @default.
- W2339941932 hasPrimaryLocation W23399419321 @default.
- W2339941932 hasRelatedWork W1672313078 @default.
- W2339941932 hasRelatedWork W1972656728 @default.
- W2339941932 hasRelatedWork W1989772702 @default.
- W2339941932 hasRelatedWork W2000799481 @default.
- W2339941932 hasRelatedWork W2015684586 @default.
- W2339941932 hasRelatedWork W2027414605 @default.
- W2339941932 hasRelatedWork W2075883562 @default.
- W2339941932 hasRelatedWork W2091906493 @default.
- W2339941932 hasRelatedWork W2097003187 @default.
- W2339941932 hasRelatedWork W2122096535 @default.
- W2339941932 hasRelatedWork W2140724459 @default.
- W2339941932 hasRelatedWork W2358779410 @default.
- W2339941932 hasRelatedWork W2391343177 @default.
- W2339941932 hasRelatedWork W2926191344 @default.
- W2339941932 hasRelatedWork W3030509059 @default.
- W2339941932 hasRelatedWork W3153682404 @default.
- W2339941932 hasRelatedWork W2087885481 @default.
- W2339941932 hasRelatedWork W2185275413 @default.
- W2339941932 hasRelatedWork W2859353272 @default.
- W2339941932 hasRelatedWork W2869317975 @default.
- W2339941932 isParatext "false" @default.
- W2339941932 isRetracted "false" @default.
- W2339941932 magId "2339941932" @default.
- W2339941932 workType "article" @default.