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• W2340029360 abstract "Background: Vascular endothelial growth factor (VEGF) plays a crucial role in tumor angiogenesis and growth in most solid neoplasia. Materials and Methods: Clonal tumor cell lines expressing varying levels of this pro-angiogenic factor were created via recombinant adeno-associated virus infection of a human (HT29) and rodent (SCCVII) tumor model. Results: The alteration in VEGF expression levels did not significantly impact the in vitro growth rate of the clonal cell lines or the expression levels of other known pro-angiogenic factors. However, the tumors that arose from these clonal cell lines did display significant physiological differences. Up- regulation of VEGF expression increased the in vivo growth rate and the intratumoral vessel density of the resulting tumors and decreased the extent of tumor necrosis. Conclusion: Since the tumor vascular network can impact the efficacy of anti- cancer therapies, these results suggest that VEGF expression may be important to consider in the treatment of cancer. Angiogenesis, the growth of new blood vessels from existing vasculature, is an important physiological process that is fundamental in wound healing, reproduction and development (1). Endothelial cells are usually quiescent in normal tissues, dividing, approximately, once every seven years. However, in a variety of pathological disorders, including cancer, the growth rate of endothelial cells can be rapidly accelerated, with divisions occurring as fast as once a week (2). This angiogenic switch has been shown to be vital to the growth of a tumor beyond a diameter of, approximately, 1-2 mm (3). The complex process of angiogenesis is a tightly regulated balance between endogenous factors that can either promote or inhibit new vessel growth (4). Angiogenic stimulators include basic fibroblast growth factor (bFGF) (5), platelet-derived growth factor (PDGF) (6), the angiopoietins (Ang-1 and Ang-2) (7, 8) and the vascular endothelial growth factor (VEGF) (9). Of these, VEGF is considered to be the key regulator of growth in a wide variety of tumor types (10)." @default.
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• W2340029360 date "2006-11-01" @default.
• W2340029360 modified "2023-09-24" @default.
• W2340029360 title "Impact of VEGF expression on the physiological characteristics of clonal cell lines." @default.
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