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- W2340104051 abstract "The present review summarizes data on 5-hydroxymethylcytosine - a modification of cytosine with a recently discovered epigenetic effect. The biochemical mechanisms of 5-hydroxymethylcytosine formation and further modification in the mammalian genome are discussed; the role of 5-hydroxymethylcytosine in the epigenetic reprogramming during mammalian gametogenesis and early embryogenesis as well as in the regulation of gene expression is analyzed; data on the diseases and the adverse environmental factors, linked to the DNA hydroxymethyaltion disruptions is shown." @default.
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- W2340104051 date "2014-03-15" @default.
- W2340104051 modified "2023-09-24" @default.
- W2340104051 title "Oxidized form of 5-methylcytosine - 5-hydroxymethylcytosine: a new insight into the biological significance in the mammalian genome" @default.
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- W2340104051 doi "https://doi.org/10.17816/ecogen1213-13" @default.
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