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- W2340145902 abstract "Abstract The purpose of this study was to determine whether antiorthostatic suspension of C3HeB/FeJ mice for a period of 11 days affected macrophage and spleen cell function. We found that antiorthostatic suspension did not alter macrophage secretion of prostaglandin E2, tumor necrosis factor α, and interleukin-1. Antiorthostatic suspension also did not affect macrophage-mediated contact-dependent cytotoxicity, TNF-mediated cytotoxicity, expression of class II histocompatibility molecules, or concanavalin A and Bandeiraea simplicifolia lectin binding sites. The proliferative response of splenic T cells in response to mitogens and staphylococcal exotoxins was significantly enhanced in antiorthostatically suspended mice. We detected significantly higher concentrations of corticosterone in the plasma of antiorthostatically suspended mice. Therefore, there did not appear to be any direct immunosuppressive effects of corticosterone on the parameters tested." @default.
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- W2340145902 date "1992-08-01" @default.
- W2340145902 modified "2023-10-03" @default.
- W2340145902 title "Effects of antiorthostatic suspension and corticosterone on macrophage and spleen cell function" @default.
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- W2340145902 doi "https://doi.org/10.1002/jlb.52.2.202" @default.
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