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• W2340145994 abstract "This study was done to investigate effects of antioxidant supplementation on phytohemagglutinin(PHA)-stimulated interleukin-2(IL-2) production by peripheral blood mononuclear cells(PBMCs) in elderly women. This study was designed as a placebo-controlled, single-blinded, randomized intervention trial. Twenty four elderly women aged over 60years, visitings social welfare center in Seoul were divided into 3 groups, placebo(n = 8), vitamin C supplemented (n = 8), and vitamin E supplemented(n = 8) groups. Experimental groups were given either 1000mg of L-ascorbic acid or 400 IU of d-α-tocopherol for 4 weeks. There was no significant difference in antioxidant vitamins intakes and their plasma levels among pre-intervention groups. Plasma viatmin C or E levels was significantly increased after vitamin C or E supplementations. The increases of plasma thiobarbituric acid-reactive substance(TBARS) levels in the placebo group were significantly higher than those of the supplemented 2 groups. There were no significant differences in the changes of plasma IL-2 level between pre- and post-intervention among the 3 groups. However there was a significant increase in PHAstimulated IL-2 production by PBMCs after 4-week vitamin E or vitamin C supplementation. Particularly, vitamin E supplemented group showed a higher PHA-stimulated IL-2 production than vitamin C supplemented group. These results indicate that vitamin E or vitamin C supplementation might enhance mitogen-stimulated cytokine production by immune cells, which could be one of the factors to improve health status in the elderly." @default.
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• W2340145994 date "2005-03-01" @default.
• W2340145994 modified "2023-09-28" @default.
• W2340145994 title "Effects of Antioxidant Supplementation on Antioxidant Status and PHA-Stimulated Interleukin-2 Production by Peripheral Blood Mononuclear Cells in the Elderly Women" @default.
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