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- W2340176611 abstract "目的 探讨慢性乙型肝炎（CHB）患者外周血CD4^＋CD25^＋CD127^low/-调节性T细胞与肝组织HBV-cccDNA及HBV-DNA载量、血清HBV-DNA载量、肝脏病理及肝功能的相关性。方法 采用流式细胞仪检测30例CHB及30例健康体检者外周血CD4^＋CD25^＋CD127^low/-调节性T细胞占CD4~＋T细胞百分率;并对其中22例患者行肝组织活检,采用实时荧光定量聚合酶链反应（FQ-PCR）检测CHB患者肝组织HBV-cccDNA、HBV-DNA载量;肝组织进行苏木素-伊红（HE）染色、Masson染色、网染、VG染色,行炎症（G）分级及纤维化（S）分期;同期检测肝功能ALT水平,并对各检测值进行比较和相关性分析。结果 CHB患者外周血CD4^＋CD25^＋CD127^low/-Treg细胞的百分率为（9.27±2.07）%,明显高于健康对照组（4.96±0.97）%,差异具有统计学意义（P〈0.05）;CHB患者外周血CD4^＋CD25^＋CD127^low/-Treg细胞与血清HBV DNA（lgIU/mL）载量呈正相关（Pearson相关系数r=0.38,P〈0.05）;与肝组织HBV-cccDNA及HBV-DNA（lgcps/mg）均无明显相关性（Pearson相关系数r分别为0.162、0.306,两者均P〉0.05）;与肝组织炎症级别及纤维化分期均无明显相关性（Spearman秩相关系数r分别为0.056、-0.047,两者均为P〉0.05）;与ALT亦无明显相关性（Pearson相关系数r=0.044,P〉0.05）。结论 慢性乙型肝炎患者外周血CD4^＋CD25^＋CD127^low/-Treg细胞水平明显升高且与血清HBV-DNA载量呈正相关,提示Treg细胞在慢性乙型肝炎中发挥着重要的负性免疫调节作用,可能是导致病毒复制持续存在的重要因素。" @default.
- W2340176611 created "2016-06-24" @default.
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- W2340176611 date "2016-01-01" @default.
- W2340176611 modified "2023-09-24" @default.
- W2340176611 title "慢性乙型肝炎患者外周血CD4^＋CD25^＋CD127^（low/-）调节性T细胞表达及其与肝组织病理、HBV-cccDNA的关系" @default.
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