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• W2340222018 abstract "A study was planned with the ethanol extract of leaves of Melothria maderaspatana (Family: Cucurbitaceae) to check its effects on intestinal glucose absorption and insulin secretion. The results showed that the extract (0.156, 0.312, 0.625, 1.25, 2.5 and 5 mg/mL) demonstrated a significant reduction in glucose absorption in a dose dependant manner. A maximum inhibition was observed at 2.5 mg/mL. The promotion of the extract on insulin secretion was confirmed by incubating β-cell of pancreatic islets and INS-1E insulinoma cells with the extract (1-1000 µg/mL). Administration of extract at 100 and 200 mg/kg p.o. in an oral glucose tolerance test (OGTT) led to a significant fall in plasma glucose level in 30 minutes after the administration in normal C57BL/6 mice compared to untreated (p<0.05)." @default.
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• W2340222018 date "2011-01-01" @default.
• W2340222018 modified "2023-09-27" @default.
• W2340222018 title "Ethanol Extract of Melothria Maderaspatana Inhibits Glucose Absorption and Stimulates Insulin Secretion in Male C57BL/6 Mice" @default.
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