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• W2340251856 endingPage "1782" @default.
• W2340251856 startingPage "1770" @default.
• W2340251856 abstract "We previously demonstrated an accumulation of tumor-reactive CD4(+) CD8(+) double positive (DP) T cells within melanoma-infiltrating lymphocytes, supporting their role in the regulation of anti-tumor immune responses. Similarly to their CD8(+) counterparts, intra-tumor DP T cells are MHC class-I restricted but differed by a limited lytic activity against autologous melanoma cells. Based on these observations and to further characterize DP T cells, both populations were compared at the transcriptional level. Our results revealed the overexpression of the IL-9 receptor (IL-9R) by DP T cells and prompted us to investigate the impact of IL-9 on their biology. We show that IL-9 favors DP T-cell survival by protecting them from apoptosis and by promoting their proliferation. In addition, IL-9 enhances their ability to produce cytokines and increased their levels of granzyme B/perforin as well as degranulation capacity, leading to a strengthened cytotoxic activity against melanoma cells. Taken together, the IL-9R(high) DP T-cell population could be a new preferential target for IL-9, which could take part in their retention within the melanoma infiltrate while also favoring their anti-tumor activity. More generally, our results extend the pleiotropic effects of IL-9 to IL-9R-expressing intra-tumor T cells, which could further potentiate anti-tumor immune responses." @default.
• W2340251856 created "2016-06-24" @default.
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• W2340251856 date "2016-05-06" @default.
• W2340251856 modified "2023-10-17" @default.
• W2340251856 title "IL-9 promotes the survival and function of human melanoma-infiltrating CD4⁺CD8⁺double-positive T cells" @default.
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• W2340251856 doi "https://doi.org/10.1002/eji.201546061" @default.
• W2340251856 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27094152" @default.
• W2340251856 hasPublicationYear "2016" @default.
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