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- W2340299743 abstract "Two hundred and eighty nine unrelated Marathas residing in Mumbai, Maharastra, (Western In- dia) were studied for HLA A, B, C and DR locus antigen profiles. The HLA antigen maximum likelihood gene fre- quencies of HLA A1, A2, A9 (24), A11, A19 (33), B5, B7, B35, B40 (61), Cw3, Cw6, DR2, DR5, DR7, DQ1 and DQ2 were increased while that of HLA A3, A10 (26), A36, B8, B13, B16 (38), B18, B21, B22 (55), B53, B73, Cw5, Cw7, DR3, DR4, DR9, and DQ3 were decreased in the Marathas. HLA antigens A25 (10), B14, B39 (16), B54 (22), B56 (22), B58 (17) and Cw8 were not identi- fied in the present investigation. Two Locus haplotype analyses revealed the presence of A10-B8, A1-B17, A24- B52, B5-Cw9, B13-Cw3, B15-Cw2, B35-Cw4, DR2-DQ1, DR5-DQ3 and DR1-DQ9 haplotypes with positive link- age disequilibrium among the marathas. Haplotype A2- B12 was the only haplotype identified in negative link- age disequilibrium. The observed maximum likelihood gene frequencies, haplotype frequencies and linkage dis- equilibrium in Marathas suggest the influence of genetic drift caused by selection, geography and culture. Further the study reveals that the Hindu population of India can- not be considered as a single panmictic population due to vast allelic diversity and immense heterozygosity in haplotypes." @default.
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- W2340299743 date "2001-06-08" @default.
- W2340299743 modified "2023-09-27" @default.
- W2340299743 title "HLA Antigen Distribution in Maratha Community from Mumbai, Maharastra, India" @default.
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- W2340299743 doi "https://doi.org/10.31901/24566330.2001/01.03.02" @default.
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