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- W2340306072 abstract "Myoporum laetum (ngaino) is a hepatotoxic plant that contain furanosesquiterpenoid essential oils (FSTs) such as ngaione. Poisoning cause marked elevation of the serum levels of AST, GGT and total bilirubin.. A total of 7 sheep and 6 steers were dosed just once with 20 or 30g/kg of green leaves of Myoporum laetum. Blood samples and hepatic biopsies were taken before and 1, 3 and 7 days after dosage. In sheep the serum levels of AST, GGT and total bilirubin increased even before 24 hours after dosing the plant in all experimental animals, except for the controls. Histological findings in sheep included hepatocyte vacuolization, portal fibrosis, proliferation of biliary ducts and necrosis of periportal hepatocytes. In cattle both, the serum enzymatic activity and histological changes, were less evident. Concerning disease evolution, there was positive correlation between clinical signs, enzymatic activity and histological changes." @default.
- W2340306072 created "2016-06-24" @default.
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- W2340306072 date "2004-01-01" @default.
- W2340306072 modified "2023-09-27" @default.
- W2340306072 title "Observações clínicas e bioquímicas em ovinos e bovinos intoxicados experimentalmente por Myoporum laetum * Clinical and biochemical findings in Myoporum laetum experimentally poisoned sheep and cattle" @default.
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