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- W2340309034 endingPage "79" @default.
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- W2340309034 abstract "Background: Over the last four decades, the use of water soluble polymers in rational formulation design has rapidly evolved into valuable drug delivery strategies to enhance the safety and therapeutic effectiveness of poorly soluble drugs, particularly anticancer drugs. Novel advances in polymer chemistry have provided new generations of well defined polymeric architectures for specific applications in polymer-drug conjugate design. However, total control of crucial parameters such as particle size, molecular weight distribution, polydispersity, localization of charges, hydrophilic-lipophilic balance and non site-specific coupling reactions during conjugation has been a serious challenge. Objective: This review briefly describes the current advances in polymer-drug nanoconjugate design and various challenges hindering their transformation into clinically useful medicines. Method: Existing literature was reviewed. Results: This review provides insights into the significant impact of covalent and non-covalent interactions between drug and polymer on drug loading [or conjugation] efficiency, conjugate stability, mechanism of drug release from the conjugate and biopharmaceutical properties of poorly soluble drugs. The utility values and application of Quality by Design principles in rational design, optimization and control of the Critical Quality Attributes [CQA] and Critical Process Parameters [CPP] that underpin the safety, quality and efficacy of the nanoconjugates are also presented. Conclusion: It was apparent that better understanding of the physicochemical properties of the nanoconjugates as well as the drug-polymer interaction during conjugation process is essential to be able to control the biodistribution, pharmacokinetics, therapeutic activity and toxicity of the nanoconjugates which will in turn enhance the prospect of successful transformation of these promising nanoconjugates into clinically useful nanomedicines. Keywords: Controlled biodistribution, critical quality attributes, nanoconjugate stability, polymer-drug nanoconjugates, poorly soluble drugs, rational formulation design." @default.
- W2340309034 created "2016-06-24" @default.
- W2340309034 creator A5009747591 @default.
- W2340309034 creator A5042841785 @default.
- W2340309034 creator A5050304101 @default.
- W2340309034 creator A5051837272 @default.
- W2340309034 creator A5055714443 @default.
- W2340309034 creator A5076700975 @default.
- W2340309034 date "2016-04-13" @default.
- W2340309034 modified "2023-10-18" @default.
- W2340309034 title "Polymer-Drug Nanoconjugate – An Innovative Nanomedicine: Challenges and Recent Advancements in Rational Formulation Design for Effective Delivery of Poorly Soluble Drugs" @default.
- W2340309034 cites W100328325 @default.
- W2340309034 cites W109788472 @default.
- W2340309034 cites W1264540065 @default.
- W2340309034 cites W13849965 @default.
- W2340309034 cites W1488083143 @default.
- W2340309034 cites W1490299254 @default.
- W2340309034 cites W1498305210 @default.
- W2340309034 cites W1555210583 @default.
- W2340309034 cites W1555994455 @default.
- W2340309034 cites W1564937578 @default.
- W2340309034 cites W1590254871 @default.
- W2340309034 cites W1772079981 @default.
- W2340309034 cites W1792622797 @default.
- W2340309034 cites W1830217992 @default.
- W2340309034 cites W1899397722 @default.
- W2340309034 cites W1929461104 @default.
- W2340309034 cites W1956944003 @default.
- W2340309034 cites W1975530828 @default.
- W2340309034 cites W1976041621 @default.
- W2340309034 cites W1976057940 @default.
- W2340309034 cites W1977983687 @default.
- W2340309034 cites W1978183755 @default.
- W2340309034 cites W1978627145 @default.
- W2340309034 cites W1979867927 @default.
- W2340309034 cites W1982267003 @default.
- W2340309034 cites W1983162648 @default.
- W2340309034 cites W1984829006 @default.
- W2340309034 cites W1985858988 @default.
- W2340309034 cites W1986329432 @default.
- W2340309034 cites W1986497300 @default.
- W2340309034 cites W1987119060 @default.
- W2340309034 cites W1988260454 @default.
- W2340309034 cites W1988709547 @default.
- W2340309034 cites W1989067119 @default.
- W2340309034 cites W1989353157 @default.
- W2340309034 cites W1989886196 @default.
- W2340309034 cites W1990163407 @default.
- W2340309034 cites W1990939755 @default.
- W2340309034 cites W1991300039 @default.
- W2340309034 cites W1993234385 @default.
- W2340309034 cites W1995591348 @default.
- W2340309034 cites W1999813833 @default.
- W2340309034 cites W2000691433 @default.
- W2340309034 cites W2001981530 @default.
- W2340309034 cites W2002456671 @default.
- W2340309034 cites W2005244999 @default.
- W2340309034 cites W2006439379 @default.
- W2340309034 cites W2006626262 @default.
- W2340309034 cites W2007983670 @default.
- W2340309034 cites W2008000140 @default.
- W2340309034 cites W2008160002 @default.
- W2340309034 cites W2009749128 @default.
- W2340309034 cites W2010163679 @default.
- W2340309034 cites W2011370547 @default.
- W2340309034 cites W2011873158 @default.
- W2340309034 cites W2011886457 @default.
- W2340309034 cites W2014873133 @default.
- W2340309034 cites W2016156919 @default.
- W2340309034 cites W2019375221 @default.
- W2340309034 cites W2020322655 @default.
- W2340309034 cites W2020373947 @default.
- W2340309034 cites W2021192090 @default.
- W2340309034 cites W2021243298 @default.
- W2340309034 cites W2023177796 @default.
- W2340309034 cites W2023338638 @default.
- W2340309034 cites W2024315050 @default.
- W2340309034 cites W2024524719 @default.
- W2340309034 cites W2024710619 @default.
- W2340309034 cites W2024787650 @default.
- W2340309034 cites W2025036947 @default.
- W2340309034 cites W2025707409 @default.
- W2340309034 cites W2027137358 @default.
- W2340309034 cites W2028893730 @default.
- W2340309034 cites W2029135196 @default.
- W2340309034 cites W2029619161 @default.
- W2340309034 cites W2030855909 @default.
- W2340309034 cites W2031033175 @default.
- W2340309034 cites W2031630601 @default.
- W2340309034 cites W2032367161 @default.
- W2340309034 cites W2035926815 @default.
- W2340309034 cites W2036665433 @default.
- W2340309034 cites W2037048276 @default.
- W2340309034 cites W2037123852 @default.
- W2340309034 cites W2037808957 @default.
- W2340309034 cites W2038375984 @default.
- W2340309034 cites W2038552054 @default.
- W2340309034 cites W2038882972 @default.