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- W2340309723 abstract "Abstract In spite of the recent interest and advances in linear controllability of complex networks, controlling nonlinear network dynamics remains an outstanding problem. Here we develop an experimentally feasible control framework for nonlinear dynamical networks that exhibit multistability. The control objective is to apply parameter perturbation to drive the system from one attractor to another, assuming that the former is undesired and the latter is desired. To make our framework practically meaningful, we consider restricted parameter perturbation by imposing two constraints: it must be experimentally realizable and applied only temporarily. We introduce the concept of attractor network, which allows us to formulate a quantifiable controllability framework for nonlinear dynamical networks: a network is more controllable if the attractor network is more strongly connected. We test our control framework using examples from various models of experimental gene regulatory networks and demonstrate the beneficial role of noise in facilitating control." @default.
- W2340309723 created "2016-06-24" @default.
- W2340309723 creator A5019554559 @default.
- W2340309723 creator A5027042016 @default.
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- W2340309723 creator A5050109554 @default.
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- W2340309723 date "2016-04-14" @default.
- W2340309723 modified "2023-10-18" @default.
- W2340309723 title "A geometrical approach to control and controllability of nonlinear dynamical networks" @default.
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- W2340309723 doi "https://doi.org/10.1038/ncomms11323" @default.
- W2340309723 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4834635" @default.
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- W2340309723 hasPublicationYear "2016" @default.
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