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• W2340346417 abstract "Managing expensive technology is a debated issue in modern radiation oncology. Proton beam therapy (PBT) represents, considering its cost and its foreseen benefits, a typical case of discussion waiting for more robust results demonstrating the presumable clinical gains against the available radiation therapy (XRT) treatment alternatives based on the use of photons. The treatment with particles utilizes many different beams (neutrons, protons, pions, or helium, neon, argon, and carbon ions) that represent a distinct entity respect conventional XRT which uses photons. PBT is the most common form of heavy-particle radiation therapy used so far; it is not a new invention, being its clinical use proposed in a seminal article by R. Wilson in 1946[1] and the first patients treated in 1954 at the Lawrence Berkeley National Laboratory in California[2]. Since cyclotron or synchrotron, used to accelerate protons to therapeutic energies, were used primarily for research in particle or nuclear physics, the initial clinical activity in proton therapy was carried out in research facilities and the use of protons in clinical practice has grown slowly for several years in non-clinical setting. More than fifty years later, after a long period of seminal work in a limited number of Institutions, PBT has gained public attention in recent years because of the rapidly increasing number of centers around the world, regardless of their high cost. Hospital-based proton beam facilities have been in operation since 1990 after the opening of the first dedicated clinical center at Loma Linda Medical University Center in California - US. Since that years, commercial entities began to build cyclotrons and synchrotrons for clinical purposes. Over the last 10 years, PBT has gathered more interest in the scientific community and more media and patient attention and is now flourishing in the US and abroad. As of December, 2015, 57 proton therapy centers are in operation worldwide, others are under construction and many more in a planning phase[3]. Most patients who have been treated with heavy-particle therapy were treated with protons: PTCOG (Particle Therapy Co-Operative Group) reports that between 1954 and 2014, 137 000 patients globally received part or all of their radiation therapy with particles, and in particular 86% of them with protons[4]. The generation of these particles and the building of dedicated centers, however, requires large investments and operational costs and big infrastructure. Only relatively few studies have demonstrated the effectiveness of proton therapy and the effects are surrounded with uncertainty[5] being the cost-effectiveness still the core of the controversy around the use of PBT." @default.
• W2340346417 created "2016-06-24" @default.
• W2340346417 creator A5076548341 @default.
• W2340346417 date "2016-01-01" @default.
• W2340346417 modified "2023-09-27" @default.
• W2340346417 title "The actual Interest in Radiotherapy for the Utilization of Proton Beam, Highlighting Physics Basis, Technology and Common Clinical Indications" @default.
• W2340346417 cites W1494104030 @default.
• W2340346417 cites W1496390158 @default.
• W2340346417 cites W1752066105 @default.
• W2340346417 cites W1909155065 @default.
• W2340346417 cites W1916212991 @default.
• W2340346417 cites W1955759814 @default.
• W2340346417 cites W1964536172 @default.
• W2340346417 cites W1965029673 @default.
• W2340346417 cites W1966418691 @default.
• W2340346417 cites W1967804683 @default.
• W2340346417 cites W1969555548 @default.
• W2340346417 cites W1973318362 @default.
• W2340346417 cites W1979169907 @default.
• W2340346417 cites W1980879738 @default.
• W2340346417 cites W1983805637 @default.
• W2340346417 cites W1989329231 @default.
• W2340346417 cites W1990963883 @default.
• W2340346417 cites W1993220206 @default.
• W2340346417 cites W1999189079 @default.
• W2340346417 cites W2001093915 @default.
• W2340346417 cites W2005021430 @default.
• W2340346417 cites W2007005344 @default.
• W2340346417 cites W2012218138 @default.
• W2340346417 cites W2012638724 @default.
• W2340346417 cites W2013837909 @default.
• W2340346417 cites W2024061066 @default.
• W2340346417 cites W2026281945 @default.
• W2340346417 cites W2030475888 @default.
• W2340346417 cites W2033262318 @default.
• W2340346417 cites W2039379124 @default.
• W2340346417 cites W2040145532 @default.
• W2340346417 cites W2048507575 @default.
• W2340346417 cites W2053700561 @default.
• W2340346417 cites W2058025276 @default.
• W2340346417 cites W2059737260 @default.
• W2340346417 cites W2060396831 @default.
• W2340346417 cites W2067077649 @default.
• W2340346417 cites W2067453542 @default.
• W2340346417 cites W2073093286 @default.
• W2340346417 cites W2074561351 @default.
• W2340346417 cites W2077506633 @default.
• W2340346417 cites W2078051053 @default.
• W2340346417 cites W2083812135 @default.
• W2340346417 cites W2083960546 @default.
• W2340346417 cites W2086862863 @default.
• W2340346417 cites W2093871427 @default.
• W2340346417 cites W2094084295 @default.
• W2340346417 cites W2096258236 @default.
• W2340346417 cites W2098112001 @default.
• W2340346417 cites W2098443648 @default.
• W2340346417 cites W2098733695 @default.
• W2340346417 cites W2101440857 @default.
• W2340346417 cites W2102409653 @default.
• W2340346417 cites W2103404859 @default.
• W2340346417 cites W2103922547 @default.
• W2340346417 cites W2106493887 @default.
• W2340346417 cites W2108607266 @default.
• W2340346417 cites W2110876229 @default.
• W2340346417 cites W2113193425 @default.
• W2340346417 cites W2113207830 @default.
• W2340346417 cites W2113553944 @default.
• W2340346417 cites W2117275139 @default.
• W2340346417 cites W2120392388 @default.
• W2340346417 cites W2124143747 @default.
• W2340346417 cites W2131204998 @default.
• W2340346417 cites W2133184525 @default.
• W2340346417 cites W2134773558 @default.
• W2340346417 cites W2135271691 @default.
• W2340346417 cites W2137020482 @default.
• W2340346417 cites W2139511451 @default.
• W2340346417 cites W2141150135 @default.
• W2340346417 cites W2143622647 @default.
• W2340346417 cites W2151663771 @default.
• W2340346417 cites W2153952941 @default.
• W2340346417 cites W2155341270 @default.
• W2340346417 cites W2189691749 @default.
• W2340346417 cites W2213300340 @default.
• W2340346417 cites W2238478156 @default.
• W2340346417 cites W2261340646 @default.
• W2340346417 cites W2263581080 @default.
• W2340346417 cites W2271996082 @default.
• W2340346417 cites W2320553148 @default.
• W2340346417 cites W2327269198 @default.
• W2340346417 cites W2327411323 @default.
• W2340346417 cites W2331921534 @default.
• W2340346417 cites W2401644291 @default.
• W2340346417 cites W3144729699 @default.
• W2340346417 doi "https://doi.org/10.17554/j.issn.1819-6187.2016.04.90" @default.
• W2340346417 hasPublicationYear "2016" @default.
• W2340346417 type Work @default.
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