Matches in SemOpenAlex for { <https://semopenalex.org/work/W2340371382> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2340371382 abstract "To investigate the auto-induction of cytochrome P450 (CYP450) by Chloroxoquinoline (CXL), a novel anticancer drug. Three experiments related to the induction of CYP450 were performed: a) In vitro use of the rat fresh hepatocytes model; b) In vivo 'cocktail' of CYP450 probe model; c) Pharmacokinetic (PK) study of the single and multiple doses. Some typical CYP enzyme probes and inducers were used in these experiments and were all determined by HPLC-MS/MS. The expression levels of CYP3A and CYP1A mRNA were analyzed by the real time polymerase chain reaction (RT-PCR) technique. The PK studies showed that the area under the curve (AUC0-t) and the peak concentration (Cmax) of the multiple doses were approximately 2.4-fold and 1.9-fold lower than those of the single dose, respectively (p < 0.05). Subsequent studies were conducted to study the possible induction of CXL on CYP 450. The in vivo 'cocktail' administration of CYP450 probe model indicated that 5 d pretreatment with CXL resulted in a mean 4.6 times increase in the metabolites/probe plasma ratios for CYP 3A and a 336% increase for CYP 1A than those of the negative control (p < 0.05). The induction effect of CXL on CYP450 was further evaluated on rat hepatocytes with four concentrations (1, 10, 50 and 100 μmol/L). Compared with the negative control, the mRNA levels of CYP 1A2 increased significantly in rat hepatocytes after treatment with 10, 50 and 100 μmol/L CXL (p < 0.05). While significant inductions of CYP 3A1 were observed in the entire treated groups. The results of the present study demonstrate enhanced and induced expression of CYP 3A and CYP 1A in response to CXL exposure in rats, suggesting that CXL is an auto-inducer of CYP 3A and CYP 1A." @default.
- W2340371382 created "2016-06-24" @default.
- W2340371382 creator A5006429209 @default.
- W2340371382 creator A5013516483 @default.
- W2340371382 creator A5034282402 @default.
- W2340371382 creator A5036123911 @default.
- W2340371382 creator A5049692788 @default.
- W2340371382 creator A5060002817 @default.
- W2340371382 creator A5067817218 @default.
- W2340371382 creator A5078729046 @default.
- W2340371382 date "2015-09-23" @default.
- W2340371382 modified "2023-09-27" @default.
- W2340371382 title "Auto-Induction Effect of Chloroxoquinoline on the Cytochrome P450 Enzymes of Rats Associated with CYP 3A and 1A" @default.
- W2340371382 cites W1520418202 @default.
- W2340371382 cites W1825214245 @default.
- W2340371382 cites W1975882704 @default.
- W2340371382 cites W1997271604 @default.
- W2340371382 cites W2001488867 @default.
- W2340371382 cites W2012863453 @default.
- W2340371382 cites W2019189967 @default.
- W2340371382 cites W2029294514 @default.
- W2340371382 cites W2040546709 @default.
- W2340371382 cites W2052889769 @default.
- W2340371382 cites W2095442432 @default.
- W2340371382 cites W2107450474 @default.
- W2340371382 cites W2115650781 @default.
- W2340371382 cites W2152964734 @default.
- W2340371382 cites W2161894198 @default.
- W2340371382 cites W2405533122 @default.
- W2340371382 doi "https://doi.org/10.1371/journal.pone.0138875" @default.
- W2340371382 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4580629" @default.
- W2340371382 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26397835" @default.
- W2340371382 hasPublicationYear "2015" @default.
- W2340371382 type Work @default.
- W2340371382 sameAs 2340371382 @default.
- W2340371382 citedByCount "1" @default.
- W2340371382 countsByYear W23403713822017 @default.
- W2340371382 crossrefType "journal-article" @default.
- W2340371382 hasAuthorship W2340371382A5006429209 @default.
- W2340371382 hasAuthorship W2340371382A5013516483 @default.
- W2340371382 hasAuthorship W2340371382A5034282402 @default.
- W2340371382 hasAuthorship W2340371382A5036123911 @default.
- W2340371382 hasAuthorship W2340371382A5049692788 @default.
- W2340371382 hasAuthorship W2340371382A5060002817 @default.
- W2340371382 hasAuthorship W2340371382A5067817218 @default.
- W2340371382 hasAuthorship W2340371382A5078729046 @default.
- W2340371382 hasBestOaLocation W23403713821 @default.
- W2340371382 hasConcept C112705442 @default.
- W2340371382 hasConcept C11824378 @default.
- W2340371382 hasConcept C132154277 @default.
- W2340371382 hasConcept C150903083 @default.
- W2340371382 hasConcept C181199279 @default.
- W2340371382 hasConcept C185592680 @default.
- W2340371382 hasConcept C202751555 @default.
- W2340371382 hasConcept C207001950 @default.
- W2340371382 hasConcept C22979827 @default.
- W2340371382 hasConcept C526171541 @default.
- W2340371382 hasConcept C55493867 @default.
- W2340371382 hasConcept C86803240 @default.
- W2340371382 hasConcept C98274493 @default.
- W2340371382 hasConceptScore W2340371382C112705442 @default.
- W2340371382 hasConceptScore W2340371382C11824378 @default.
- W2340371382 hasConceptScore W2340371382C132154277 @default.
- W2340371382 hasConceptScore W2340371382C150903083 @default.
- W2340371382 hasConceptScore W2340371382C181199279 @default.
- W2340371382 hasConceptScore W2340371382C185592680 @default.
- W2340371382 hasConceptScore W2340371382C202751555 @default.
- W2340371382 hasConceptScore W2340371382C207001950 @default.
- W2340371382 hasConceptScore W2340371382C22979827 @default.
- W2340371382 hasConceptScore W2340371382C526171541 @default.
- W2340371382 hasConceptScore W2340371382C55493867 @default.
- W2340371382 hasConceptScore W2340371382C86803240 @default.
- W2340371382 hasConceptScore W2340371382C98274493 @default.
- W2340371382 hasLocation W23403713821 @default.
- W2340371382 hasLocation W23403713822 @default.
- W2340371382 hasLocation W23403713823 @default.
- W2340371382 hasLocation W23403713824 @default.
- W2340371382 hasLocation W23403713825 @default.
- W2340371382 hasOpenAccess W2340371382 @default.
- W2340371382 hasPrimaryLocation W23403713821 @default.
- W2340371382 hasRelatedWork W1491964893 @default.
- W2340371382 hasRelatedWork W1566015146 @default.
- W2340371382 hasRelatedWork W2050275393 @default.
- W2340371382 hasRelatedWork W2057097799 @default.
- W2340371382 hasRelatedWork W2132019166 @default.
- W2340371382 hasRelatedWork W2276256235 @default.
- W2340371382 hasRelatedWork W2605594768 @default.
- W2340371382 hasRelatedWork W3000071749 @default.
- W2340371382 hasRelatedWork W3080423469 @default.
- W2340371382 hasRelatedWork W3191460019 @default.
- W2340371382 isParatext "false" @default.
- W2340371382 isRetracted "false" @default.
- W2340371382 magId "2340371382" @default.
- W2340371382 workType "article" @default.