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- W2340374405 abstract "During the life of humans and animals, dysfunctional cells undergo apoptosis in an active and programmed fashion, a process that allows the organism to function normally. The program to enter apoptosis is present in each cell of the body and “waits” for an apoptosis signal. Such signals can be either extracellular or intracellular (1). The process of apoptosis can be divided into two parts: the decision phase and the execution phase. During the decision phase, a cascade of gene-regulated processes is activated that leads to the actual execution of apoptosis. At each step of the decision cascade, the apoptotic signal can be either prevented/delayed or stimulated, which implies that cells have genes with pro- and antiapoptotic activities (2). During the execution phase, cellular processes take place that will lead to a total metamorphosis of the cell. Specifically, the cellular membrane forms so-called blebbing structures, and the DNA in the nucleus strongly condenses. Somewhat later, the cell will disintegrate into several fragments, the so-called apoptotic bodies. These bodies are taken up and digested by neighboring cells and macrophages, which prevents the release of cellular debris that cause inflammatory reactions in the body (3)." @default.
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- W2340374405 date "2002-01-01" @default.
- W2340374405 modified "2023-09-23" @default.
- W2340374405 title "Apoptin as an Anticancer Therapy" @default.
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- W2340374405 doi "https://doi.org/10.1007/978-1-59259-153-4_13" @default.
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