FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2340376798> ?p ?o ?g. }

• W2340376798 endingPage "4074" @default.
• W2340376798 startingPage "4064" @default.
• W2340376798 abstract "Abstract Fc receptor–like (FCRL) 5 is a novel IgG binding protein expressed on B cells, with the capacity to regulate Ag receptor signaling. We assessed FCRL5 expression on circulating B cells from healthy donors and found that FCRL5+ cells are most enriched among atypical CD21−/lo/CD27− tissue-like memory (TLM) B cells, which are abnormally expanded in several autoimmune and infectious diseases. Using multicolor flow cytometry, FCRL5+ TLM cells were found to express more CD11c and several inhibitory receptors than did the FCRL5− TLM subset. The homing receptor profiles of the two TLM subsets shared features consistent with migration away from lymphoid tissues, but they also displayed distinct differences. Analysis of IgH V regions in single cells indicated that although both subsets are diverse, the FCRL5+ subset accumulated significantly more somatic mutations. Furthermore, the FCRL5+ subset had more switched isotype expression and more extensive proliferative history. Microarray analysis and quantitative RT-PCR demonstrated that the two TLM subsets possess distinct gene expression profiles, characterized by markedly different CD11c, SOX5, T-bet, and RTN4R expression, as well as differences in expression of inhibitory receptors. Functional analysis revealed that the FCRL5+ TLM subset responds poorly to multiple stimuli compared with the FCRL5− subset, as reflected by reduced calcium mobilization and blunted cell proliferation. We propose that the FCRL5+ TLM subset, but not the FCRL5− TLM subset, underwent Ag-driven development and is severely dysfunctional. The present study elucidates the heterogeneity of TLM B cells and provides the basis to dissect their roles in the pathogenesis of inflammatory and infectious diseases." @default.
• W2340376798 created "2016-06-24" @default.
• W2340376798 creator A5025804896 @default.
• W2340376798 creator A5034961989 @default.
• W2340376798 creator A5048639910 @default.
• W2340376798 creator A5061418519 @default.
• W2340376798 date "2016-05-15" @default.
• W2340376798 modified "2023-10-10" @default.
• W2340376798 title "Fc Receptor–like 5 Expression Distinguishes Two Distinct Subsets of Human Circulating Tissue–like Memory B Cells" @default.
• W2340376798 cites W1540043982 @default.
• W2340376798 cites W1569221343 @default.
• W2340376798 cites W1798290921 @default.
• W2340376798 cites W1857670989 @default.
• W2340376798 cites W1896170955 @default.
• W2340376798 cites W1922066493 @default.
• W2340376798 cites W1971833928 @default.
• W2340376798 cites W1973881600 @default.
• W2340376798 cites W1986512556 @default.
• W2340376798 cites W1989708237 @default.
• W2340376798 cites W1992004393 @default.
• W2340376798 cites W1992511689 @default.
• W2340376798 cites W1997105134 @default.
• W2340376798 cites W2008838198 @default.
• W2340376798 cites W2009626568 @default.
• W2340376798 cites W2010127459 @default.
• W2340376798 cites W2019447967 @default.
• W2340376798 cites W2022391508 @default.
• W2340376798 cites W2052279754 @default.
• W2340376798 cites W2058506362 @default.
• W2340376798 cites W2062121087 @default.
• W2340376798 cites W2071368241 @default.
• W2340376798 cites W2081255498 @default.
• W2340376798 cites W2081287805 @default.
• W2340376798 cites W2084669174 @default.
• W2340376798 cites W2100025622 @default.
• W2340376798 cites W2101495681 @default.
• W2340376798 cites W2104934866 @default.
• W2340376798 cites W2110840300 @default.
• W2340376798 cites W2114551673 @default.
• W2340376798 cites W2118425309 @default.
• W2340376798 cites W2122167372 @default.
• W2340376798 cites W2123674097 @default.
• W2340376798 cites W2137489521 @default.
• W2340376798 cites W2139255187 @default.
• W2340376798 cites W2140335888 @default.
• W2340376798 cites W2142802169 @default.
• W2340376798 cites W2147953838 @default.
• W2340376798 cites W2151536565 @default.
• W2340376798 cites W2158528364 @default.
• W2340376798 cites W2164343118 @default.
• W2340376798 cites W2164793815 @default.
• W2340376798 cites W2165018534 @default.
• W2340376798 cites W2171744407 @default.
• W2340376798 cites W2210810009 @default.
• W2340376798 doi "https://doi.org/10.4049/jimmunol.1501027" @default.
• W2340376798 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27076679" @default.
• W2340376798 hasPublicationYear "2016" @default.
• W2340376798 type Work @default.
• W2340376798 sameAs 2340376798 @default.
• W2340376798 citedByCount "59" @default.
• W2340376798 countsByYear W23403767982016 @default.
• W2340376798 countsByYear W23403767982017 @default.
• W2340376798 countsByYear W23403767982018 @default.
• W2340376798 countsByYear W23403767982019 @default.
• W2340376798 countsByYear W23403767982020 @default.
• W2340376798 countsByYear W23403767982021 @default.
• W2340376798 countsByYear W23403767982022 @default.
• W2340376798 countsByYear W23403767982023 @default.
• W2340376798 crossrefType "journal-article" @default.
• W2340376798 hasAuthorship W2340376798A5025804896 @default.
• W2340376798 hasAuthorship W2340376798A5034961989 @default.
• W2340376798 hasAuthorship W2340376798A5048639910 @default.
• W2340376798 hasAuthorship W2340376798A5061418519 @default.
• W2340376798 hasBestOaLocation W23403767981 @default.
• W2340376798 hasConcept C104317684 @default.
• W2340376798 hasConcept C127716648 @default.
• W2340376798 hasConcept C153911025 @default.
• W2340376798 hasConcept C170493617 @default.
• W2340376798 hasConcept C203014093 @default.
• W2340376798 hasConcept C2779919695 @default.
• W2340376798 hasConcept C54355233 @default.
• W2340376798 hasConcept C553184892 @default.
• W2340376798 hasConcept C86803240 @default.
• W2340376798 hasConcept C95444343 @default.
• W2340376798 hasConceptScore W2340376798C104317684 @default.
• W2340376798 hasConceptScore W2340376798C127716648 @default.
• W2340376798 hasConceptScore W2340376798C153911025 @default.
• W2340376798 hasConceptScore W2340376798C170493617 @default.
• W2340376798 hasConceptScore W2340376798C203014093 @default.
• W2340376798 hasConceptScore W2340376798C2779919695 @default.
• W2340376798 hasConceptScore W2340376798C54355233 @default.
• W2340376798 hasConceptScore W2340376798C553184892 @default.
• W2340376798 hasConceptScore W2340376798C86803240 @default.
• W2340376798 hasConceptScore W2340376798C95444343 @default.
• W2340376798 hasIssue "10" @default.
• W2340376798 hasLocation W23403767981 @default.
• W2340376798 hasLocation W23403767982 @default.
• W2340376798 hasOpenAccess W2340376798 @default.

• next