FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2340377903> ?p ?o ?g. }

• W2340377903 endingPage "2883" @default.
• W2340377903 startingPage "2876" @default.
• W2340377903 abstract "Abstract Better understanding of hemostasis will be possible by the identification of new lineage-specific stimuli that regulate platelet formation. We describe a novel functional megakaryocyte receptor that belongs to a family of ionotropic glutamate receptors of theN-methyl-d-aspartate (NMDA) subtype responsible for synaptic neurotransmission in the central nervous system (CNS). Northern blotting and reverse-transcriptase polymerase chain reaction (RT-PCR) studies identified expression of NMDAR1 and NMDAR2D type subunit mRNA in rat marrow, human megakaryocytes, and MEG-01 clonal megakaryoblastic cells. Immunohistochemistry and in vivo autoradiographic binding of the NMDA receptor-specific antagonist MK-801 confirmed that megakaryocytes expressed open channel-forming NMDA receptors in vivo. Western blots indicated that megakaryocyte NMDAR1 was either unglycosylated or only glycosylated to low levels, and of identical size to CNS-type NMDAR1 after deglycosylation with endoglycosidase F/peptide-N-glycosidase F. In functional studies, we demonstrated that NMDA receptor activity was necessary for phorbol myristate acetate (PMA)-induced differentiation of megakaryoblastic cells; NMDA receptor blockade by specific antagonists significantly inhibited PMA-mediated increases in cell size, CD41 expression, and adhesion of MEG-01 cells. These results provide evidence for a novel pathway by which megakaryocytopoiesis and platelet production may be regulated." @default.
• W2340377903 created "2016-06-24" @default.
• W2340377903 creator A5036194428 @default.
• W2340377903 creator A5037600539 @default.
• W2340377903 creator A5041571091 @default.
• W2340377903 creator A5041621090 @default.
• W2340377903 creator A5044415925 @default.
• W2340377903 creator A5060339009 @default.
• W2340377903 creator A5063210480 @default.
• W2340377903 creator A5064265315 @default.
• W2340377903 date "1999-05-01" @default.
• W2340377903 modified "2023-09-26" @default.
• W2340377903 title "Expression of a Functional N-Methyl-d-Aspartate–Type Glutamate Receptor by Bone Marrow Megakaryocytes" @default.
• W2340377903 cites W1517934429 @default.
• W2340377903 cites W1523926085 @default.
• W2340377903 cites W1539488577 @default.
• W2340377903 cites W1544803716 @default.
• W2340377903 cites W1606045266 @default.
• W2340377903 cites W1800713457 @default.
• W2340377903 cites W1965354507 @default.
• W2340377903 cites W1965375035 @default.
• W2340377903 cites W1967373341 @default.
• W2340377903 cites W1971133960 @default.
• W2340377903 cites W1975596000 @default.
• W2340377903 cites W1983612778 @default.
• W2340377903 cites W1985639768 @default.
• W2340377903 cites W1992414754 @default.
• W2340377903 cites W1994195148 @default.
• W2340377903 cites W1994729983 @default.
• W2340377903 cites W2000791344 @default.
• W2340377903 cites W2006380933 @default.
• W2340377903 cites W2016575029 @default.
• W2340377903 cites W2023178348 @default.
• W2340377903 cites W2028137290 @default.
• W2340377903 cites W2029184215 @default.
• W2340377903 cites W2033685577 @default.
• W2340377903 cites W2035339470 @default.
• W2340377903 cites W2037529527 @default.
• W2340377903 cites W2038818733 @default.
• W2340377903 cites W2043986638 @default.
• W2340377903 cites W2045707567 @default.
• W2340377903 cites W2049511526 @default.
• W2340377903 cites W2053540221 @default.
• W2340377903 cites W2053980736 @default.
• W2340377903 cites W2057460995 @default.
• W2340377903 cites W2059334396 @default.
• W2340377903 cites W2061846425 @default.
• W2340377903 cites W2067129052 @default.
• W2340377903 cites W2068723146 @default.
• W2340377903 cites W2071978401 @default.
• W2340377903 cites W2074331062 @default.
• W2340377903 cites W2077348695 @default.
• W2340377903 cites W2082365797 @default.
• W2340377903 cites W2091061989 @default.
• W2340377903 cites W2111062311 @default.
• W2340377903 cites W2114918609 @default.
• W2340377903 cites W2120699640 @default.
• W2340377903 cites W2129108032 @default.
• W2340377903 cites W2131326834 @default.
• W2340377903 cites W2160210296 @default.
• W2340377903 cites W2189022852 @default.
• W2340377903 cites W2238894705 @default.
• W2340377903 cites W2318488092 @default.
• W2340377903 cites W2399186719 @default.
• W2340377903 cites W2468385423 @default.
• W2340377903 cites W2471747790 @default.
• W2340377903 cites W4250676767 @default.
• W2340377903 doi "https://doi.org/10.1182/blood.v93.9.2876" @default.
• W2340377903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10216082" @default.
• W2340377903 hasPublicationYear "1999" @default.
• W2340377903 type Work @default.
• W2340377903 sameAs 2340377903 @default.
• W2340377903 citedByCount "72" @default.
• W2340377903 countsByYear W23403779032012 @default.
• W2340377903 countsByYear W23403779032013 @default.
• W2340377903 countsByYear W23403779032014 @default.
• W2340377903 countsByYear W23403779032015 @default.
• W2340377903 countsByYear W23403779032016 @default.
• W2340377903 countsByYear W23403779032017 @default.
• W2340377903 countsByYear W23403779032018 @default.
• W2340377903 countsByYear W23403779032020 @default.
• W2340377903 countsByYear W23403779032021 @default.
• W2340377903 countsByYear W23403779032022 @default.
• W2340377903 crossrefType "journal-article" @default.
• W2340377903 hasAuthorship W2340377903A5036194428 @default.
• W2340377903 hasAuthorship W2340377903A5037600539 @default.
• W2340377903 hasAuthorship W2340377903A5041571091 @default.
• W2340377903 hasAuthorship W2340377903A5041621090 @default.
• W2340377903 hasAuthorship W2340377903A5044415925 @default.
• W2340377903 hasAuthorship W2340377903A5060339009 @default.
• W2340377903 hasAuthorship W2340377903A5063210480 @default.
• W2340377903 hasAuthorship W2340377903A5064265315 @default.
• W2340377903 hasConcept C126322002 @default.
• W2340377903 hasConcept C134018914 @default.
• W2340377903 hasConcept C153911025 @default.
• W2340377903 hasConcept C170493617 @default.
• W2340377903 hasConcept C201750760 @default.
• W2340377903 hasConcept C2777918643 @default.

• next