FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2340381126> ?p ?o ?g. }

• W2340381126 endingPage "634" @default.
• W2340381126 startingPage "619" @default.
• W2340381126 abstract "Polychlorinated biphenyl (PCB) concentrations reported in preferred prey and blubber of bottlenose dolphins from the Turtle-Brunswick River estuary (Georgia, USA) suggest the potential for adverse effects. However, PCBs in Turtle-Brunswick River estuary dolphins are primarily derived from Aroclor 1268, and predicting toxic effects of Aroclor 1268 is uncertain because of the mixture's unique composition and associated physiochemical characteristics. These differences suggest that toxicity benchmarks for other PCB mixtures may not be relevant to dolphins exposed to Aroclor 1268. American mink (Neovison vison) were used as a surrogate model for cetaceans to characterize mechanisms of action associated with Aroclor 1268 exposure. Mink share similarities in phylogeny and life history with cetaceans and are characteristically sensitive to PCBs, making them an attractive surrogate species for marine mammals in ecotoxicity studies. Adult female mink and a subsequent F1 generation were exposed to Aroclor 1268 through diet, and effects on enzyme induction, histopathology, thyroid hormone regulation, hematology, organ weights, and body condition index were compared to a negative control and a 3,3',4,4',5-pentachlorobiphenyl (PCB 126)-positive control. Aroclor 1268 dietary exposure concentrations ranged from 1.8 µg/g wet weight to 29 µg/g wet weight. Anemia, hypothyroidism, and hepatomegaly were observed in mink exposed to Aroclor 1268 beyond various dietary thresholds. Cytochrome P450 induction and squamous epithelial proliferation jaw lesions were low in Aroclor 1268 treatments relative to the positive control. Differences in enzyme induction and the development of squamous epithelial proliferation jaw lesions between Aroclor 1268 treatments and the positive control, coupled with effects observed in Aroclor 1268 treatments not observed in the positive control, indicate that mechanisms additional to the aryl hydrocarbon receptor-mediated pathway are associated with Aroclor 1268 exposure." @default.
• W2340381126 created "2016-06-24" @default.
• W2340381126 creator A5003356714 @default.
• W2340381126 creator A5019883157 @default.
• W2340381126 creator A5053543763 @default.
• W2340381126 creator A5054760108 @default.
• W2340381126 creator A5068225519 @default.
• W2340381126 creator A5069065790 @default.
• W2340381126 creator A5074190500 @default.
• W2340381126 creator A5082027268 @default.
• W2340381126 date "2016-02-05" @default.
• W2340381126 modified "2023-10-16" @default.
• W2340381126 title "Enzyme induction and histopathology elucidate aryl hydrocarbon receptor-mediated versus non-aryl hydrocarbon receptor-mediated effects of Aroclor 1268 in American mink (<i>Neovison vison</i>)" @default.
• W2340381126 cites W1821733801 @default.
• W2340381126 cites W1935479846 @default.
• W2340381126 cites W1968876380 @default.
• W2340381126 cites W1969351720 @default.
• W2340381126 cites W1970577590 @default.
• W2340381126 cites W1970932650 @default.
• W2340381126 cites W1972658490 @default.
• W2340381126 cites W1974004535 @default.
• W2340381126 cites W1984946671 @default.
• W2340381126 cites W1988599281 @default.
• W2340381126 cites W1990726783 @default.
• W2340381126 cites W1996010126 @default.
• W2340381126 cites W1999876958 @default.
• W2340381126 cites W2013915612 @default.
• W2340381126 cites W2020014074 @default.
• W2340381126 cites W2025894136 @default.
• W2340381126 cites W2030174954 @default.
• W2340381126 cites W2036413416 @default.
• W2340381126 cites W2047841435 @default.
• W2340381126 cites W2048271154 @default.
• W2340381126 cites W2049819085 @default.
• W2340381126 cites W2051474983 @default.
• W2340381126 cites W2052742384 @default.
• W2340381126 cites W2055442562 @default.
• W2340381126 cites W2061933584 @default.
• W2340381126 cites W2063659671 @default.
• W2340381126 cites W2066097900 @default.
• W2340381126 cites W2081992887 @default.
• W2340381126 cites W2088940121 @default.
• W2340381126 cites W2092896555 @default.
• W2340381126 cites W2094170989 @default.
• W2340381126 cites W2098123343 @default.
• W2340381126 cites W2101868189 @default.
• W2340381126 cites W2104284672 @default.
• W2340381126 cites W2106104112 @default.
• W2340381126 cites W2106745004 @default.
• W2340381126 cites W2108287931 @default.
• W2340381126 cites W2109333829 @default.
• W2340381126 cites W2111693321 @default.
• W2340381126 cites W2113750680 @default.
• W2340381126 cites W2125463148 @default.
• W2340381126 cites W2125669941 @default.
• W2340381126 cites W2129674110 @default.
• W2340381126 cites W2129817356 @default.
• W2340381126 cites W2133158707 @default.
• W2340381126 cites W2137380608 @default.
• W2340381126 cites W2142616400 @default.
• W2340381126 cites W2144662564 @default.
• W2340381126 cites W2156172478 @default.
• W2340381126 cites W2156515956 @default.
• W2340381126 cites W2157246267 @default.
• W2340381126 cites W2159952658 @default.
• W2340381126 cites W2165627850 @default.
• W2340381126 cites W2166161376 @default.
• W2340381126 cites W2167952887 @default.
• W2340381126 cites W4241219529 @default.
• W2340381126 doi "https://doi.org/10.1002/etc.3203" @default.
• W2340381126 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26267837" @default.
• W2340381126 hasPublicationYear "2016" @default.
• W2340381126 type Work @default.
• W2340381126 sameAs 2340381126 @default.
• W2340381126 citedByCount "3" @default.
• W2340381126 countsByYear W23403811262016 @default.
• W2340381126 countsByYear W23403811262017 @default.
• W2340381126 countsByYear W23403811262018 @default.
• W2340381126 crossrefType "journal-article" @default.
• W2340381126 hasAuthorship W2340381126A5003356714 @default.
• W2340381126 hasAuthorship W2340381126A5019883157 @default.
• W2340381126 hasAuthorship W2340381126A5053543763 @default.
• W2340381126 hasAuthorship W2340381126A5054760108 @default.
• W2340381126 hasAuthorship W2340381126A5068225519 @default.
• W2340381126 hasAuthorship W2340381126A5069065790 @default.
• W2340381126 hasAuthorship W2340381126A5074190500 @default.
• W2340381126 hasAuthorship W2340381126A5082027268 @default.
• W2340381126 hasConcept C104317684 @default.
• W2340381126 hasConcept C115346097 @default.
• W2340381126 hasConcept C126322002 @default.
• W2340381126 hasConcept C134018914 @default.
• W2340381126 hasConcept C142724271 @default.
• W2340381126 hasConcept C18903297 @default.
• W2340381126 hasConcept C2776365360 @default.
• W2340381126 hasConcept C2780754187 @default.
• W2340381126 hasConcept C29730261 @default.
• W2340381126 hasConcept C33070731 @default.
• W2340381126 hasConcept C33594762 @default.

• next