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- W2340390041 abstract "Chronic hepatitis C virus (HCV) infection affects nearly 3 million Americans, most of whom are unaware they are infected. Although only a small percentage develop cirrhosis, they represent the largest category of liver-transplant recipients. Interferon alpha-2a (IF) therapy is only mildly effective in controlling or eliminating viremia, improving liver function, and retarding cirrhosis; its efficacy is approximately doubled with co-administered ribavirin, but even then, about 60 percent of patients remain viremic when therapy ceases. Peginterferon alpha-2a (PIF), IF with a polyethylene glycol molecule added, was developed to maintain blood levels (and thus antiviral efficacy) longer than IF, avoiding viral rebound between dosing and permitting once-weekly use. In …" @default.
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- W2340390041 date "2000-01-01" @default.
- W2340390041 modified "2023-09-27" @default.
- W2340390041 title "Peginterferon Alpha-2a: Improved Therapy for Chronic Hepatitis C, Including Cirrhosis" @default.
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- W2340390041 doi "https://doi.org/10.1056/id200012210000001" @default.
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