FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2340392685> ?p ?o ?g. }

• W2340392685 abstract "Irritable bowel syndrome (IBS) is the most common functional gastrointestinal disorder (FGID) characterised by abdominal pain and associated with altered bowel habits. There is no cure for IBS and treatment is limited to symptom management strategies. Common approaches to control symptoms associated with IBS include pharmacological agents, dietary therapies and psychological treatments. There is high-quality evidence of efficacy for the low FODMAP (Fermentable Oligosaccharides, Disaccharides, Monosaccharides And Polyols) diet but the gluten-free diet is also being increasingly applied. In fact, non-coeliac gluten sensitivity (NCGS), defined by the worsening of symptoms when consuming gluten and the improvement of symptoms on a gluten-free diet, is now considered a distinct clinical entity. Psychological treatments are also being increasingly sought but how their efficacy compares with that of dietary approaches is unknown. This thesis contains a series of studies which aimed to 1) gain a greater understanding of the differences, similarities and possible overlap between IBS and NCGS; 2) fill gaps in evidence regarding effects of gluten ingestion on extraintestinal symptoms in patients with NCGS; 3) develop a method for the large-scale isolation of gliadin suitable for human feeding trials; and 4) examine the efficacy of gut-directed hypnotherapy compared to that of the low FODMAP diet.Initial results from a double-blind, placebo-controlled, randomised, cross-over trial in 22 participants were suggestive of gluten-specific changes to current feelings of depression in patients with NCGS but more detailed analysis in a different cohort of patients with NCGS failed to reproduce this effect. Notably, additional investigations showed no evidence of gluten-specific worsening of any psychological indices, quality of life, fatigue or gastrointestinal symptoms. The only exception was a small increase in response times on the Subtle Cognitive Impairment Test (SCIT). Overall, these studies failed to support a specific entity of NCGS in patients who would otherwise be classified as having IBS or another FGID. A method for the large-scale isolation of gliadin suitable for human consumption was successful. However, the lack of specific gluten-mediated effects precluded the planned study of purified gliadin in defining its role in symptom induction in patients with NCGS.How effective psychological therapies might be for IBS was addressed in a randomised un-blinded study in 78 participants with IBS comparing the relative efficacy of gut-directed hypnotherapy with that of the more established ‘gold standard’, the low FODMAP diet, alone or in combination. In terms of effect on gastrointestinal symptoms and quality of life, both therapies were similarly efficacious over 6 months, but without additive effects. Gut-directed hypnotherapy had additional psychological benefits. These results indicate that gut-directed hypnotherapy should be considered a viable modality and applied as a primary therapy for patients with IBS.In conclusion, this thesis has made a considerable contribution to our understanding of the association between psychological health and FGID and has fulfilled its aims. First, it provides high-quality evidence that gluten ingestion is unlikely to be associated with the worsening of psychological (or gastrointestinal) manifestations in patients with self-reported NCGS and questions the existence of the latter as a specific entity. Secondly, a procedure was developed to enable future study of the responsible moiety for gluten-mediated effects. Thirdly, it provides compelling evidence that gut-directed hypnotherapy is a viable therapeutic option for the treatment of IBS. Further research into mechanisms of action and predictors of response, as well as subtle effects of gluten on cognition, is warranted." @default.
• W2340392685 created "2016-06-24" @default.
• W2340392685 creator A5077448626 @default.
• W2340392685 date "2016-01-01" @default.
• W2340392685 modified "2023-09-24" @default.
• W2340392685 title "Exploring the link between mental health and functional gastrointestinal disorders" @default.
• W2340392685 cites W1549140114 @default.
• W2340392685 cites W1562131205 @default.
• W2340392685 cites W1869880021 @default.
• W2340392685 cites W1923128715 @default.
• W2340392685 cites W1964244234 @default.
• W2340392685 cites W1967808671 @default.
• W2340392685 cites W1967848019 @default.
• W2340392685 cites W1981140923 @default.
• W2340392685 cites W1982697648 @default.
• W2340392685 cites W1983033237 @default.
• W2340392685 cites W1999665482 @default.
• W2340392685 cites W2009747911 @default.
• W2340392685 cites W2014161061 @default.
• W2340392685 cites W2014568016 @default.
• W2340392685 cites W2022163857 @default.
• W2340392685 cites W2022299487 @default.
• W2340392685 cites W2023601145 @default.
• W2340392685 cites W2028056942 @default.
• W2340392685 cites W2035683776 @default.
• W2340392685 cites W2035744743 @default.
• W2340392685 cites W2036052530 @default.
• W2340392685 cites W2038748292 @default.
• W2340392685 cites W2057031657 @default.
• W2340392685 cites W2062141055 @default.
• W2340392685 cites W2069634861 @default.
• W2340392685 cites W2069947117 @default.
• W2340392685 cites W2084517125 @default.
• W2340392685 cites W2087118124 @default.
• W2340392685 cites W2093420688 @default.
• W2340392685 cites W2093637875 @default.
• W2340392685 cites W2098567963 @default.
• W2340392685 cites W2103300456 @default.
• W2340392685 cites W2111866907 @default.
• W2340392685 cites W2121415197 @default.
• W2340392685 cites W2124408605 @default.
• W2340392685 cites W2129991789 @default.
• W2340392685 cites W2139950277 @default.
• W2340392685 cites W2140546870 @default.
• W2340392685 cites W2142564910 @default.
• W2340392685 cites W2150386100 @default.
• W2340392685 cites W2163324123 @default.
• W2340392685 cites W2165199863 @default.
• W2340392685 cites W256453204 @default.
• W2340392685 cites W3134084687 @default.
• W2340392685 cites W642038881 @default.
• W2340392685 doi "https://doi.org/10.4225/03/58b789d4cecec" @default.
• W2340392685 hasPublicationYear "2016" @default.
• W2340392685 type Work @default.
• W2340392685 sameAs 2340392685 @default.
• W2340392685 citedByCount "0" @default.
• W2340392685 crossrefType "dissertation" @default.
• W2340392685 hasAuthorship W2340392685A5077448626 @default.
• W2340392685 hasConcept C126322002 @default.
• W2340392685 hasConcept C139719470 @default.
• W2340392685 hasConcept C141105273 @default.
• W2340392685 hasConcept C142724271 @default.
• W2340392685 hasConcept C159654299 @default.
• W2340392685 hasConcept C162324750 @default.
• W2340392685 hasConcept C203014093 @default.
• W2340392685 hasConcept C204787440 @default.
• W2340392685 hasConcept C27081682 @default.
• W2340392685 hasConcept C2776336767 @default.
• W2340392685 hasConcept C2776867660 @default.
• W2340392685 hasConcept C2778271842 @default.
• W2340392685 hasConcept C2780955771 @default.
• W2340392685 hasConcept C2781369853 @default.
• W2340392685 hasConcept C535046627 @default.
• W2340392685 hasConcept C71924100 @default.
• W2340392685 hasConcept C90924648 @default.
• W2340392685 hasConceptScore W2340392685C126322002 @default.
• W2340392685 hasConceptScore W2340392685C139719470 @default.
• W2340392685 hasConceptScore W2340392685C141105273 @default.
• W2340392685 hasConceptScore W2340392685C142724271 @default.
• W2340392685 hasConceptScore W2340392685C159654299 @default.
• W2340392685 hasConceptScore W2340392685C162324750 @default.
• W2340392685 hasConceptScore W2340392685C203014093 @default.
• W2340392685 hasConceptScore W2340392685C204787440 @default.
• W2340392685 hasConceptScore W2340392685C27081682 @default.
• W2340392685 hasConceptScore W2340392685C2776336767 @default.
• W2340392685 hasConceptScore W2340392685C2776867660 @default.
• W2340392685 hasConceptScore W2340392685C2778271842 @default.
• W2340392685 hasConceptScore W2340392685C2780955771 @default.
• W2340392685 hasConceptScore W2340392685C2781369853 @default.
• W2340392685 hasConceptScore W2340392685C535046627 @default.
• W2340392685 hasConceptScore W2340392685C71924100 @default.
• W2340392685 hasConceptScore W2340392685C90924648 @default.
• W2340392685 hasLocation W23403926851 @default.
• W2340392685 hasOpenAccess W2340392685 @default.
• W2340392685 hasPrimaryLocation W23403926851 @default.
• W2340392685 hasRelatedWork W1634005148 @default.
• W2340392685 hasRelatedWork W2022299487 @default.
• W2340392685 hasRelatedWork W2089005121 @default.
• W2340392685 hasRelatedWork W2107616948 @default.
• W2340392685 hasRelatedWork W2176098192 @default.

• next