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• W2340403224 abstract "Alcoholdependenceischaracterizedbyexcessiveconsumption,lossofcontroloverintake,andthepresenceofawithdrawalsyndrome, including both motivational and physical symptoms. The motivational symptoms, including anxiety, have been hypothesized to be important factors eliciting excessive drinking during abstinence. Previous work has shown that ethanol-dependent rats also display enhanced anxiety-like behaviors and enhanced ethanol self-administration during withdrawal, likely resulting from dysregulation of braincorticotropin-releasingfactor(CRF)stresssystems.Thepresentstudywasdesignedtoexplorethebrainsiteswithintheextended amygdala [central nucleus of the amygdala (CeA), lateral bed nucleus of the stria terminalis (BNST), and nucleus accumbens shell (NAcSh)] that mediate the increased ethanol self-administration observed during withdrawal. Ethanol-dependent animals showed an increase in ethanol self-administration after acute withdrawal relative to nondependent controls. The CRF antagonist D-Phe-CRF12‐41 ([D-Phe 12 ,Nle 21,38 ,CMeLeu 37 ]-rCRF(12‐41))wasadministeredintotheCeA,lateralBNST,orNAcShofacute-withdrawndependentand nondependentrats.AdministeredintotheCeA,theantagonistreducedethanolself-administrationindependentanimals,withnoeffect in nondependent animals. Administration of D-Phe-CRF12‐41 into the lateral BNST and NAcSh was without effect on ethanol selfadministration in dependent and nondependent animals. At the same time point of withdrawal, there was a decrease in CRF immunoreactivitywithintheCeA,suggestinganincreasedextracellularreleaseofCRFduringwithdrawal.TherewasnochangeinCRFimmunoreactivityintheBNSTorNAcSh.TheseresultsindicatethatCRF,specificallywithintheCeA,playsaroleinmediatingexcessiveethanol consumptioninethanol-dependentanimals." @default.
• W2340403224 created "2016-06-24" @default.
• W2340403224 creator A5022456330 @default.
• W2340403224 date "2006-01-01" @default.
• W2340403224 modified "2023-09-26" @default.
• W2340403224 title "Corticotropin-ReleasingFactorwithintheCentralNucleusof theAmygdalaMediatesEnhancedEthanolSelf- AdministrationinWithdrawn,Ethanol-DependentRats" @default.
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