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- W2340451106 abstract "O fator neurotrofico conhecido como BDNF tem atraido consideravel atencao na literatura cientifica, pelo seu envolvimento em processos cruciais de desenvolvimento e regulacao do sistema nervoso. Entretanto, muitos aspectos desta molecula sao ainda desconhecidos, enquanto outros foram investigados apenas em humanos e organismos-modelo. Neste contexto, ferramentas de bioinformatica podem ser muito uteis para realizar analises comparativas enfocando aspectos evolutivos, estruturais e funcionais. Este projeto objetivou uma caracterizacao de padroes de conservacao e variacao desta molecula atraves da comparacao das sequencias codificantes deste gene em diferentes linhagens de mamiferos, assim como uma investigacao de aspectos estruturais atraves da construcao de um modelo 3D do BDNF consistente com dados experimentais. Os resultados revelam padroes bastante interessantes de conservacao e variacao de sequencia em diferentes linhagens, incluindo fortes evidencias da ocorrencia de selecao natural negativa (indicando restricao a mudanca devido a relevância funcional) tanto no dominio maduro como no dominio pro. Alem disso, observou-se evidencia de selecao positiva (inducao de mudancas possivelmente adaptativas) em diferentes linhagens, em todos os casos afetando diretamente o dominio pro. Estes resultados indicam que o dominio pro apresenta grande relevância funcional, e salientam a importância de focar esforcos de investigacao experimental nesta porcao do BDNF." @default.
- W2340451106 created "2016-06-24" @default.
- W2340451106 creator A5036464330 @default.
- W2340451106 date "2010-04-28" @default.
- W2340451106 modified "2023-09-23" @default.
- W2340451106 title "Evolução e modelagem molecular do fator neurotrófico derivado do cérebro (BDNF) em mamíferos" @default.
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