FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2340472203> ?p ?o ?g. }

• W2340472203 endingPage "1756" @default.
• W2340472203 startingPage "1746" @default.
• W2340472203 abstract "Abstract Inflammatory breast cancer (IBC) is a rare and aggressive form of breast cancer that remains poorly understood at the molecular level. Comprehensive tumor profiling was performed to understand clinically actionable alterations in IBC. Targeted next-generation sequencing (NGS) and IHC were performed to identify activated pathways in IBC tumor tissues. siRNA studies examined the impact of IBC genomic variants in cellular models. IBC tumor tissues were further characterized for immune infiltration and immune checkpoint expression by IHC. Genomic analysis identified recurrent alterations in core biologic pathways, including activating and targetable variants in HER/PI3K/mTOR signaling. High rates of activating HER3 point mutations were discovered in IBC tumors. Cell line studies confirmed a role for mutant HER3 in IBC cell proliferation. Immunologic analysis revealed a subset of IBC tumors associated with high CD8+/PD-L1+ lymphocyte infiltration. Immune infiltration positively correlated with an NGS-based estimate of neoantigen exposure derived from the somatic mutation rate and mutant allele frequency, iScore. Additionally, DNA mismatch repair alterations, which may contribute to higher iScores, occurred at greater frequency in tumors with higher immune infiltration. Our study identifies genomic alterations that mechanistically contribute to oncogenic signaling in IBC and provides a genetic basis for the selection of clinically relevant targeted and combination therapeutic strategies. Furthermore, an NGS-based estimate of neoantigen exposure developed in this study (iScore) may be a useful biomarker to predict immune infiltration in IBC and other cancers. The iScore may be associated with greater levels of response to immunotherapies, such as PD-L1/PD-1–targeted therapies. Mol Cancer Ther; 15(7); 1746–56. ©2016 AACR." @default.
• W2340472203 created "2016-06-24" @default.
• W2340472203 creator A5001000201 @default.
• W2340472203 creator A5006560755 @default.
• W2340472203 creator A5011906255 @default.
• W2340472203 creator A5032987754 @default.
• W2340472203 creator A5037786564 @default.
• W2340472203 creator A5045818507 @default.
• W2340472203 creator A5049961374 @default.
• W2340472203 creator A5075462213 @default.
• W2340472203 creator A5081353089 @default.
• W2340472203 creator A5085870277 @default.
• W2340472203 date "2016-07-01" @default.
• W2340472203 modified "2023-09-22" @default.
• W2340472203 title "Genomic and Immunological Tumor Profiling Identifies Targetable Pathways and Extensive CD8+/PDL1+ Immune Infiltration in Inflammatory Breast Cancer Tumors" @default.
• W2340472203 cites W183114306 @default.
• W2340472203 cites W1966365850 @default.
• W2340472203 cites W1971208896 @default.
• W2340472203 cites W1971843650 @default.
• W2340472203 cites W1974740818 @default.
• W2340472203 cites W1979443682 @default.
• W2340472203 cites W1980188722 @default.
• W2340472203 cites W1997579117 @default.
• W2340472203 cites W2008623356 @default.
• W2340472203 cites W2010601523 @default.
• W2340472203 cites W2012629333 @default.
• W2340472203 cites W2015565459 @default.
• W2340472203 cites W2018968534 @default.
• W2340472203 cites W2022495797 @default.
• W2340472203 cites W2028846884 @default.
• W2340472203 cites W2031277429 @default.
• W2340472203 cites W2039123767 @default.
• W2340472203 cites W2047664934 @default.
• W2340472203 cites W2050658928 @default.
• W2340472203 cites W2052766930 @default.
• W2340472203 cites W2053673624 @default.
• W2340472203 cites W2060643602 @default.
• W2340472203 cites W2067603408 @default.
• W2340472203 cites W2068920468 @default.
• W2340472203 cites W2069526613 @default.
• W2340472203 cites W2073597876 @default.
• W2340472203 cites W2076948707 @default.
• W2340472203 cites W2077907877 @default.
• W2340472203 cites W2084646940 @default.
• W2340472203 cites W2095156669 @default.
• W2340472203 cites W2101962857 @default.
• W2340472203 cites W2103808574 @default.
• W2340472203 cites W2107123646 @default.
• W2340472203 cites W2110933411 @default.
• W2340472203 cites W2113334910 @default.
• W2340472203 cites W2116158418 @default.
• W2340472203 cites W2118419063 @default.
• W2340472203 cites W2118982164 @default.
• W2340472203 cites W2119896120 @default.
• W2340472203 cites W2120338564 @default.
• W2340472203 cites W2123463863 @default.
• W2340472203 cites W2123591186 @default.
• W2340472203 cites W2124427232 @default.
• W2340472203 cites W2130690901 @default.
• W2340472203 cites W2134602956 @default.
• W2340472203 cites W2154453972 @default.
• W2340472203 cites W2155802897 @default.
• W2340472203 cites W2161791469 @default.
• W2340472203 doi "https://doi.org/10.1158/1535-7163.mct-15-0353" @default.
• W2340472203 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27196778" @default.
• W2340472203 hasPublicationYear "2016" @default.
• W2340472203 type Work @default.
• W2340472203 sameAs 2340472203 @default.
• W2340472203 citedByCount "42" @default.
• W2340472203 countsByYear W23404722032016 @default.
• W2340472203 countsByYear W23404722032017 @default.
• W2340472203 countsByYear W23404722032018 @default.
• W2340472203 countsByYear W23404722032019 @default.
• W2340472203 countsByYear W23404722032020 @default.
• W2340472203 countsByYear W23404722032021 @default.
• W2340472203 countsByYear W23404722032022 @default.
• W2340472203 countsByYear W23404722032023 @default.
• W2340472203 crossrefType "journal-article" @default.
• W2340472203 hasAuthorship W2340472203A5001000201 @default.
• W2340472203 hasAuthorship W2340472203A5006560755 @default.
• W2340472203 hasAuthorship W2340472203A5011906255 @default.
• W2340472203 hasAuthorship W2340472203A5032987754 @default.
• W2340472203 hasAuthorship W2340472203A5037786564 @default.
• W2340472203 hasAuthorship W2340472203A5045818507 @default.
• W2340472203 hasAuthorship W2340472203A5049961374 @default.
• W2340472203 hasAuthorship W2340472203A5075462213 @default.
• W2340472203 hasAuthorship W2340472203A5081353089 @default.
• W2340472203 hasAuthorship W2340472203A5085870277 @default.
• W2340472203 hasBestOaLocation W23404722031 @default.
• W2340472203 hasConcept C121332964 @default.
• W2340472203 hasConcept C121608353 @default.
• W2340472203 hasConcept C153400128 @default.
• W2340472203 hasConcept C167672396 @default.
• W2340472203 hasConcept C203014093 @default.
• W2340472203 hasConcept C2777701055 @default.
• W2340472203 hasConcept C2780839634 @default.
• W2340472203 hasConcept C502942594 @default.
• W2340472203 hasConcept C530470458 @default.

• next