Matches in SemOpenAlex for { <https://semopenalex.org/work/W2340473208> ?p ?o ?g. }
- W2340473208 endingPage "43" @default.
- W2340473208 startingPage "28" @default.
- W2340473208 abstract "Matrix metalloproteinases belong to an enzyme family, which assure a proteolysis of practically all components of the extracellular matrix of connective tissues in normal and pathological conditions. At physiological conditions, there are evidences on the impact of this enzyme group in the embryogenesis, morphogenesis, angiogenesis, and tissue involution. The activity impairment of matrix metalloproteinases and of their specific inhibitors leads to the biosynthesis misbalance and to the degradation of extracellular matrix components; it plays a role in the development of such diseases as diabetes mellitus, rheumatoid arthritis, and arteriosclerosis. Laboratory tests and clinical investigation results confirm the role of these enzymes in tissue remodeling of different eyeball structures in glaucoma (in particular, of the trabecular meshwork and the optic disc); it leads to intraocular fluid outflow impairment and to the glaucomatous optic neuropathy development. In the review, the analysis of clinical and experimental studies is performed that are dedicated to the investigation of matrix metalloproteinases role in the pathogenesis of different glaucoma types, of the possibility to use them as biomarkers, as well as therapeutic action targets in this disease." @default.
- W2340473208 created "2016-06-24" @default.
- W2340473208 creator A5021708002 @default.
- W2340473208 creator A5034142875 @default.
- W2340473208 creator A5038026299 @default.
- W2340473208 creator A5043265112 @default.
- W2340473208 date "2015-12-15" @default.
- W2340473208 modified "2023-09-26" @default.
- W2340473208 title "The role of matrix metalloproteinases in glaucoma pathogenesis" @default.
- W2340473208 cites W1968064807 @default.
- W2340473208 cites W1969074359 @default.
- W2340473208 cites W1969653655 @default.
- W2340473208 cites W1972384545 @default.
- W2340473208 cites W1977730659 @default.
- W2340473208 cites W1978539254 @default.
- W2340473208 cites W1980852716 @default.
- W2340473208 cites W1981793422 @default.
- W2340473208 cites W1984401984 @default.
- W2340473208 cites W1984458231 @default.
- W2340473208 cites W1991027599 @default.
- W2340473208 cites W1994849038 @default.
- W2340473208 cites W1997874027 @default.
- W2340473208 cites W2000085293 @default.
- W2340473208 cites W2000470200 @default.
- W2340473208 cites W2001287954 @default.
- W2340473208 cites W2002771508 @default.
- W2340473208 cites W2003310452 @default.
- W2340473208 cites W2006420763 @default.
- W2340473208 cites W2006796007 @default.
- W2340473208 cites W2007456079 @default.
- W2340473208 cites W2018182454 @default.
- W2340473208 cites W2022352073 @default.
- W2340473208 cites W2026037246 @default.
- W2340473208 cites W2026316653 @default.
- W2340473208 cites W2030937653 @default.
- W2340473208 cites W2031792215 @default.
- W2340473208 cites W2035444744 @default.
- W2340473208 cites W2035938109 @default.
- W2340473208 cites W2038353560 @default.
- W2340473208 cites W2043068076 @default.
- W2340473208 cites W2043243292 @default.
- W2340473208 cites W2044566561 @default.
- W2340473208 cites W2046294864 @default.
- W2340473208 cites W2050232773 @default.
- W2340473208 cites W2050632988 @default.
- W2340473208 cites W2052911528 @default.
- W2340473208 cites W2057512153 @default.
- W2340473208 cites W2057836968 @default.
- W2340473208 cites W2057858586 @default.
- W2340473208 cites W2058913320 @default.
- W2340473208 cites W2059045737 @default.
- W2340473208 cites W2059593140 @default.
- W2340473208 cites W2059925177 @default.
- W2340473208 cites W2060387702 @default.
- W2340473208 cites W2061277647 @default.
- W2340473208 cites W2062122607 @default.
- W2340473208 cites W2062322287 @default.
- W2340473208 cites W2063435758 @default.
- W2340473208 cites W2066098313 @default.
- W2340473208 cites W2068232370 @default.
- W2340473208 cites W2069512783 @default.
- W2340473208 cites W2071253071 @default.
- W2340473208 cites W2071276534 @default.
- W2340473208 cites W2072840073 @default.
- W2340473208 cites W2073259535 @default.
- W2340473208 cites W2076748689 @default.
- W2340473208 cites W2077122861 @default.
- W2340473208 cites W2086264288 @default.
- W2340473208 cites W2086319396 @default.
- W2340473208 cites W2086425072 @default.
- W2340473208 cites W2088223428 @default.
- W2340473208 cites W2092244737 @default.
- W2340473208 cites W2093856903 @default.
- W2340473208 cites W2094442778 @default.
- W2340473208 cites W2099151597 @default.
- W2340473208 cites W2100591986 @default.
- W2340473208 cites W2101995519 @default.
- W2340473208 cites W2103868159 @default.
- W2340473208 cites W2104463359 @default.
- W2340473208 cites W2104810311 @default.
- W2340473208 cites W2114881362 @default.
- W2340473208 cites W2134769368 @default.
- W2340473208 cites W2135124962 @default.
- W2340473208 cites W2151565416 @default.
- W2340473208 cites W2154401382 @default.
- W2340473208 cites W2160605010 @default.
- W2340473208 cites W2163670330 @default.
- W2340473208 cites W2163925135 @default.
- W2340473208 cites W2313266450 @default.
- W2340473208 cites W2313993513 @default.
- W2340473208 cites W332252442 @default.
- W2340473208 cites W2051889003 @default.
- W2340473208 doi "https://doi.org/10.17816/ov2015328-43" @default.
- W2340473208 hasPublicationYear "2015" @default.
- W2340473208 type Work @default.
- W2340473208 sameAs 2340473208 @default.
- W2340473208 citedByCount "6" @default.
- W2340473208 countsByYear W23404732082018 @default.