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- W2340477557 abstract "5039 Epithelial to mesenchymal transition (EMT) is a process in which cells undergo a developmental switch from epithelial to a motile mesenchymal phenotype. EMT occurs as key steps during embryonic morphogenesis, and is now implicated in the progression and metastasis of epithelial tumors. In lung cancer, the expression of individual EMT markers has been studied and correlated with prognosis. Additionally, data support a potential role of EMT as determinant of EGFR activity and predictor of EGFR tyrosine kinase inhibitor sensitivity. To better define the EMT phenotype characteristics of lung cancer and to identify potential correlations with patients’ clinicopathologic features, we studied the immunohistochemical (IHC) expression of 8 proteins, E-Cadherin, N-Cadherin, β-Catenin, Snail, MMP-P, NF-κB, Integrin-β6 and Vimentin, related to the EMT phenotype. Using formalin-fixed specimens placed in tissue microarrays 372 non-small cell lung carcinomas (NSCLC; 209 adenocarcinomas, 119 squamous cell carcinomas, 44 sarcomatoid carcinomas) and 38 small cell lung carcinomas (SCLC) were analyzed. To correlate the expression of EMT markers with EGFR abnormalities, the IHC expression of EGFR and p-EGFR was examined in all tumors. EGFR mutational status was studied in a subset of 81 adenocarcinomas. Different patterns of EMT markers expression were identified in different lung cancer histologies, with sarcomatoid carcinomas showing the lowest expression (p" @default.
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- W2340477557 date "2007-05-01" @default.
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- W2340477557 title "Epithelial mesenchymal transition phenotype correlates with lung cancer histology and EGFR abnormalities in non-small cell lung carcinoma" @default.
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