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• W2340479550 endingPage "L867" @default.
• W2340479550 startingPage "L852" @default.
• W2340479550 abstract "The variety of methods used to identify the structural determinants of anion selectivity in the cystic fibrosis transmembrane conductance regulator Cl(-) channel has made it difficult to assemble the data into a coherent framework that describes the three-dimensional structure of the pore. Here, we compare the relative importance of sites previously studied and identify new sites that contribute strongly to anion selectivity. We studied Cl(-) and substitute anions in oocytes expressing wild-type cystic fibrosis transmembrane conductance regulator or 12-pore-domain mutants to determine relative permeability and relative conductance for 9 monovalent anions and 1 divalent anion. The data indicate that the region of strong discrimination resides between T338 and S341 in transmembrane 6, where mutations affected selectivity between Cl(-) and both large and small anions. Mutations further toward the extracellular end of the pore only strongly affected selectivity between Cl(-) and larger anions. Only mutations at S341 affected selectivity between monovalent and divalent anions. The data are consistent with a narrowing of the pore between the extracellular end and a constriction near the middle of the pore." @default.
• W2340479550 created "2016-06-24" @default.
• W2340479550 creator A5006939380 @default.
• W2340479550 creator A5073085896 @default.
• W2340479550 date "2001-10-01" @default.
• W2340479550 modified "2023-10-18" @default.
• W2340479550 title "Identification of a region of strong discrimination in the pore of CFTR" @default.
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• W2340479550 doi "https://doi.org/10.1152/ajplung.2001.281.4.l852" @default.
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