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• W2340489330 endingPage "4211" @default.
• W2340489330 startingPage "4211" @default.
• W2340489330 abstract "To investigate the effect of varying levels of ocular surface stimulation on the timing and amplitude of the blink and tear secretion.Following instillation of fluorescein dye, increasing levels of air flow were directed toward the central corneas of 10 healthy subjects. Interblink interval (IBI), tear meniscus height (TMH), and fluorescence intensity were measured simultaneously. Because blinking can obscure changes in TMH, we developed novel measures of tear secretion by calculating tear meniscus fluorescein concentration (TMFC) from intensity using a mathematical model. The change of TMH and TMFC over trials and the slope of the TMFC within each IBI (IBI-TTR) were further calculated.The mean IBI was decreased by 8.08 ± 8.54 seconds from baseline to maximum air stimulation. The TMH increase was highly variable (0.41 ± 0.39 mm) among subjects, compared to the fluorescence tear turnover metrics: decrease in TMFC of 2.84 ± 0.98 natural logarithm or ln(%) and IBI-TTR of 0.065 ± 0.032 ln(%)/sec. Ocular surface stimulation was highly correlated with the TMFC and IBI-TTR, but less so with TMH (Pearson's r = 0.71, 0.69, and 0.40, P < 0.01, respectively). Blinking and tearing were significantly correlated with each other (Pearson's r = 0.56, P < 0.01), but tearing lagged behind by an average of 6.54 ± 4.07 seconds.Blinking and tearing share a common origin with sensory stimulation at the ocular surface. Both showed a dose-response increase with surface stimulation and were correlated with each other. These methods can potentially be used to understand alterations in ocular surface sensory function and associated protective responses in dry eye and other disorders of the ocular surface." @default.
• W2340489330 created "2016-06-24" @default.
• W2340489330 creator A5024381980 @default.
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• W2340489330 creator A5057970491 @default.
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• W2340489330 date "2015-07-01" @default.
• W2340489330 modified "2023-10-01" @default.
• W2340489330 title "The Effects of Increasing Ocular Surface Stimulation on Blinking and Tear Secretion" @default.
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• W2340489330 doi "https://doi.org/10.1167/iovs.14-16313" @default.
• W2340489330 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4495814" @default.
• W2340489330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26132780" @default.
• W2340489330 hasPublicationYear "2015" @default.
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