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• W2340542983 abstract "Genetic susceptibility to DNA oxidation, car- cinogen metabolism, and altered DNA repair may increase non-Hodgkin lymphoma (NHL) risk, whereas vegetables- and antioxidant-related nutrients may decrease risk. We evaluated the interaction of a priori-defined dietary factors with 28 polymorphisms in these metabolic pathways. Inci- dent cases (n = 1,141) were identified during 1998-2000 from four cancer registries and frequency-matched to pop- ulation-based controls (n = 949). We estimated diet-gene joint effects using two-phase semi-parametric maximum- likelihood methods, which utilized genotype data from all subjects as well as 371 cases and 31 1 controls with available diet information. Adjusted odds ratios (95% confidence intervals) were lower among common allele carriers with higher dietary intakes. For the GSTM3 3-base insertion and higher total vegetable intake, the risk was 0.56 (0.35-0.92, p interaction = 0.03); for GSTP1 A114V and higher cru- ciferous vegetable intake, the risk was 0.52 (0.34-0.81, p interaction = 0.02); for OGG1 S326C and higher daily zinc intake, the risk was 0.71 (0.47-1.08, p interac- tion = 0.04) and for XRCC3 T241M and higher green leafy vegetable intake, the risk was 0.63 (0.41-0.97, p interac- tion = 0.03). Calculation of the false positive report probability determined a high likelihood of falsely positive associations. Although most associations have not been examined previously with NHL, our results suggest the examined polymorphisms are not modifiers of the associa- tion between vegetable and zinc intakes and NHL risk." @default.
• W2340542983 created "2016-06-24" @default.
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• W2340542983 date "2008-01-01" @default.
• W2340542983 modified "2023-09-27" @default.
• W2340542983 title "Vegetables- and antioxidant-related nutrients, genetic susceptibility, and non-Hodgkin lymphoma risk Linda E. KelemenSophia S. WangUnhee LimWendy Cozen •" @default.
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