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• W2340594735 endingPage "1329" @default.
• W2340594735 startingPage "1329" @default.
• W2340594735 abstract "The reproductive tract secretes bioactive molecules collectively known as embryokines that can regulate embryonic growth and development. In the present study we tested four growth factors expressed in the endometrium for their ability to modify the development of the bovine embryo to the blastocyst stage and alter the expression of genes found to be upregulated (bone morphogenetic protein 15 (BMP15) and keratin 8, type II (KRT8)) or downregulated (NADH dehydrogenase 1 (ND1) and S100 calcium binding protein A10 (S100A10)) in embryos competent to develop to term. Zygotes were treated at Day 5 with 0.01, 0.1 or 1.0 nM growth factor. The highest concentration of activin A increased the percentage of putative zygotes that developed to the blastocyst stage. Connective tissue growth factor (CTGF) increased the number of cells in the inner cell mass (ICM), decreased the trophectoderm : ICM ratio and increased blastocyst expression of KRT8 and ND1. The lowest concentration of hepatocyte growth factor (HGF) reduced the percentage of putative zygotes becoming blastocysts. Teratocarcinoma-derived growth factor 1 increased total cell number at 0.01 nM and expression of S100A10 at 1.0 nM, but otherwise had no effects. Results confirm the prodevelopmental actions of activin A and indicate that CTGF may also function as an embryokine by regulating the number of ICM cells in the blastocyst and altering gene expression. Low concentrations of HGF were inhibitory to development." @default.
• W2340594735 created "2016-06-24" @default.
• W2340594735 creator A5028606515 @default.
• W2340594735 creator A5054782465 @default.
• W2340594735 creator A5090363401 @default.
• W2340594735 date "2017-01-01" @default.
• W2340594735 modified "2023-09-30" @default.
• W2340594735 title "Actions of activin A, connective tissue growth factor, hepatocyte growth factor and teratocarcinoma-derived growth factor 1 on the development of the bovine preimplantation embryo" @default.
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• W2340594735 doi "https://doi.org/10.1071/rd16033" @default.
• W2340594735 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27185102" @default.
• W2340594735 hasPublicationYear "2017" @default.
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